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SMILES: Cc1c(sc2ncnc(Nc3cccnc3OCC3CC3(F)F)c12)C(N)=O

InChI Key: InChIKey=APRGAAGUEPOUHQ-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 136226   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))		BDBM136226
PNG
(US8853193, 34-4)
Show SMILES Cc1c(sc2ncnc(Nc3cccnc3OCC3CC3(F)F)c12)C(N)=O
Show InChI InChI=1S/C17H15F2N5O2S/c1-8-11-14(22-7-23-16(11)27-12(8)13(20)25)24-10-3-2-4-21-15(10)26-6-9-5-17(9,18)19/h2-4,7,9H,5-6H2,1H3,(H2,20,25)(H,22,23,24)
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KEGG

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Similars
US Patent
n/an/a 15n/an/an/an/a7.430



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Inhibition of kinase activity of Mnk1 and Mnk2a was assessed with the same assay system, using pre-activated GST-Mnk1 or GST-Mnk2a, respectively. The...

US Patent US8853193 (2014)


BindingDB Entry DOI: 10.7270/Q2GX4983
More data for this
Ligand-Target Pair