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SMILES: COC(=O)c1sc2ncnc(Nc3cccnc3OC(C)C)c2c1C

InChI Key: InChIKey=KKBJFQSJNNQPRT-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 136227   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))		BDBM136227
PNG
(US8853193, 35)
Show SMILES COC(=O)c1sc2ncnc(Nc3cccnc3OC(C)C)c2c1C
Show InChI InChI=1S/C17H18N4O3S/c1-9(2)24-15-11(6-5-7-18-15)21-14-12-10(3)13(17(22)23-4)25-16(12)20-8-19-14/h5-9H,1-4H3,(H,19,20,21)
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MMDB

KEGG

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PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 12n/an/an/an/a7.430



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Inhibition of kinase activity of Mnk1 and Mnk2a was assessed with the same assay system, using pre-activated GST-Mnk1 or GST-Mnk2a, respectively. The...

US Patent US8853193 (2014)


BindingDB Entry DOI: 10.7270/Q2GX4983
More data for this
Ligand-Target Pair