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SMILES: Cc1c(sc2ncnc(Nc3ccc(cc3OC(CF)CF)C#N)c12)C(=O)NCCCN1CCCC1

InChI Key: InChIKey=KOWZCWMACIQPDA-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 136257   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))		BDBM136257
PNG
(US8853193, 48)
Show SMILES Cc1c(sc2ncnc(Nc3ccc(cc3OC(CF)CF)C#N)c12)C(=O)NCCCN1CCCC1
Show InChI InChI=1S/C25H28F2N6O2S/c1-16-21-23(32-19-6-5-17(14-28)11-20(19)35-18(12-26)13-27)30-15-31-25(21)36-22(16)24(34)29-7-4-10-33-8-2-3-9-33/h5-6,11,15,18H,2-4,7-10,12-13H2,1H3,(H,29,34)(H,30,31,32)
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KEGG

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Similars
US Patent
n/an/a 12n/an/an/an/a7.430



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Inhibition of kinase activity of Mnk1 and Mnk2a was assessed with the same assay system, using pre-activated GST-Mnk1 or GST-Mnk2a, respectively. The...

US Patent US8853193 (2014)


BindingDB Entry DOI: 10.7270/Q2GX4983
More data for this
Ligand-Target Pair