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SMILES: CC(CF)Oc1cc(F)ccc1Nc1ncnc2sc(C(=O)NCCCN3CCCC3)c(C)c12

InChI Key: InChIKey=UTJMDGXSKIEZQV-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 136283   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))		BDBM136283
PNG
(US8853193, 32-44)
Show SMILES CC(CF)Oc1cc(F)ccc1Nc1ncnc2sc(C(=O)NCCCN3CCCC3)c(C)c12
Show InChI InChI=1S/C24H29F2N5O2S/c1-15(13-25)33-19-12-17(26)6-7-18(19)30-22-20-16(2)21(34-24(20)29-14-28-22)23(32)27-8-5-11-31-9-3-4-10-31/h6-7,12,14-15H,3-5,8-11,13H2,1-2H3,(H,27,32)(H,28,29,30)
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MMDB

KEGG

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Similars
US Patent
n/an/a 6n/an/an/an/a7.430



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Inhibition of kinase activity of Mnk1 and Mnk2a was assessed with the same assay system, using pre-activated GST-Mnk1 or GST-Mnk2a, respectively. The...

US Patent US8853193 (2014)


BindingDB Entry DOI: 10.7270/Q2GX4983
More data for this
Ligand-Target Pair