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SMILES: CC(CF)Oc1cc(F)ccc1Nc1ncnc2sc(C(=O)NC3CCN(C)CC3)c(C)c12

InChI Key: InChIKey=MSTGHQNKKCBXMZ-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 136284   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))		BDBM136284
PNG
(US8853193, 32-45)
Show SMILES CC(CF)Oc1cc(F)ccc1Nc1ncnc2sc(C(=O)NC3CCN(C)CC3)c(C)c12
Show InChI InChI=1S/C23H27F2N5O2S/c1-13(11-24)32-18-10-15(25)4-5-17(18)29-21-19-14(2)20(33-23(19)27-12-26-21)22(31)28-16-6-8-30(3)9-7-16/h4-5,10,12-13,16H,6-9,11H2,1-3H3,(H,28,31)(H,26,27,29)
PDB
MMDB

KEGG

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PC sid
UniChem

Similars
US Patent
n/an/a 11n/an/an/an/a7.430



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Inhibition of kinase activity of Mnk1 and Mnk2a was assessed with the same assay system, using pre-activated GST-Mnk1 or GST-Mnk2a, respectively. The...

US Patent US8853193 (2014)


BindingDB Entry DOI: 10.7270/Q2GX4983
More data for this
Ligand-Target Pair