BDBM136591 US10005783, 8::US10047097, 8::US10774085, Example 8::US8865698, 8::US9676783, 8

SMILES: OC1CN(C1)C(=O)Nc1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1Cl

InChI Key: InChIKey=CIOUDHJPRJGNCX-QGZVFWFLSA-N

Data: 5 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 136591   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM136591 (US10005783, 8 | US10047097, 8 | US10774085, Exampl...) Show SMILES OC1CN(C1)C(=O)Nc1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1Cl |r| Show InChI InChI=1S/C20H20ClFN6O2/c21-15-4-3-12(22)8-14(15)17-2-1-6-27(17)18-5-7-28-19(25-18)16(9-23-28)24-20(30)26-10-13(29)11-26/h3-5,7-9,13,17,29H,1-2,6,10-11H2,(H,24,30)/t17-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	13.7	n/a	n/a	n/a	n/a	7.5	n/a
Array BioPharma Inc. US Patent					Assay Description An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...				US Patent US8865698 (2014) BindingDB Entry DOI: 10.7270/Q2B856TM
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM136591 (US10005783, 8 | US10047097, 8 | US10774085, Exampl...) Show SMILES OC1CN(C1)C(=O)Nc1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1Cl |r| Show InChI InChI=1S/C20H20ClFN6O2/c21-15-4-3-12(22)8-14(15)17-2-1-6-27(17)18-5-7-28-19(25-18)16(9-23-28)24-20(30)26-10-13(29)11-26/h3-5,7-9,13,17,29H,1-2,6,10-11H2,(H,24,30)/t17-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	13.7	n/a	n/a	n/a	n/a	7.5	n/a
Array BioPharma Inc. US Patent					Assay Description An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...				US Patent US10047097 (2018) BindingDB Entry DOI: 10.7270/Q2000442
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM136591 (US10005783, 8 | US10047097, 8 | US10774085, Exampl...) Show SMILES OC1CN(C1)C(=O)Nc1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1Cl |r| Show InChI InChI=1S/C20H20ClFN6O2/c21-15-4-3-12(22)8-14(15)17-2-1-6-27(17)18-5-7-28-19(25-18)16(9-23-28)24-20(30)26-10-13(29)11-26/h3-5,7-9,13,17,29H,1-2,6,10-11H2,(H,24,30)/t17-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	13.7	n/a	n/a	n/a	n/a	n/a	n/a
ARRAY BIOPHARMA INC. US Patent					Assay Description An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...				US Patent US10774085 (2020)
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM136591 (US10005783, 8 | US10047097, 8 | US10774085, Exampl...) Show SMILES OC1CN(C1)C(=O)Nc1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1Cl |r| Show InChI InChI=1S/C20H20ClFN6O2/c21-15-4-3-12(22)8-14(15)17-2-1-6-27(17)18-5-7-28-19(25-18)16(9-23-28)24-20(30)26-10-13(29)11-26/h3-5,7-9,13,17,29H,1-2,6,10-11H2,(H,24,30)/t17-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	13.7	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research					Assay Description Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...				Bioorg Med Chem 17: 7802-15 (2009) BindingDB Entry DOI: 10.7270/Q25H7JK7
					More data for this Ligand-Target Pair
Tyrosine kinase receptor A (TrkA) (Homo sapiens (Human))	BDBM136591 (US10005783, 8 | US10047097, 8 | US10774085, Exampl...) Show SMILES OC1CN(C1)C(=O)Nc1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1Cl |r| Show InChI InChI=1S/C20H20ClFN6O2/c21-15-4-3-12(22)8-14(15)17-2-1-6-27(17)18-5-7-28-19(25-18)16(9-23-28)24-20(30)26-10-13(29)11-26/h3-5,7-9,13,17,29H,1-2,6,10-11H2,(H,24,30)/t17-/m1/s1	PDB GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	13.7	n/a	n/a	n/a	n/a	7.5	n/a
Array BioPharma, Inc. US Patent					Assay Description Immulon 4HBX 384-well microtiter plates (Thermo part #8755) were coated with a 0.025 mg/mL solution of poly (Glu, Ala, Tyr; 6:3:1; Sigma P3899). Vari...				US Patent US9676783 (2017) BindingDB Entry DOI: 10.7270/Q26H4FK5
					More data for this Ligand-Target Pair