null

SMILES: O[C@H]1CCN(C1)C(=O)Nc1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1C(F)F

InChI Key: InChIKey=GMWUABQJDWHYLA-KBXCAEBGSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 136620   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM136620 (US10005783, 37 | US10047097, 37 | US10774085, Exam...) Show SMILES O[C@H]1CCN(C1)C(=O)Nc1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1C(F)F |r| Show InChI InChI=1S/C22H23F3N6O2/c23-13-3-4-15(20(24)25)16(10-13)18-2-1-7-30(18)19-6-9-31-21(28-19)17(11-26-31)27-22(33)29-8-5-14(32)12-29/h3-4,6,9-11,14,18,20,32H,1-2,5,7-8,12H2,(H,27,33)/t14-,18+/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	8.70	n/a	n/a	n/a	n/a	7.5	n/a
Array BioPharma Inc. US Patent					Assay Description An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...				US Patent US8865698 (2014) BindingDB Entry DOI: 10.7270/Q2B856TM
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM136620 (US10005783, 37 | US10047097, 37 | US10774085, Exam...) Show SMILES O[C@H]1CCN(C1)C(=O)Nc1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1C(F)F |r| Show InChI InChI=1S/C22H23F3N6O2/c23-13-3-4-15(20(24)25)16(10-13)18-2-1-7-30(18)19-6-9-31-21(28-19)17(11-26-31)27-22(33)29-8-5-14(32)12-29/h3-4,6,9-11,14,18,20,32H,1-2,5,7-8,12H2,(H,27,33)/t14-,18+/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	8.70	n/a	n/a	n/a	n/a	7.5	n/a
Array BioPharma Inc. US Patent					Assay Description An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...				US Patent US10047097 (2018) BindingDB Entry DOI: 10.7270/Q2000442
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM136620 (US10005783, 37 | US10047097, 37 | US10774085, Exam...) Show SMILES O[C@H]1CCN(C1)C(=O)Nc1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1C(F)F |r| Show InChI InChI=1S/C22H23F3N6O2/c23-13-3-4-15(20(24)25)16(10-13)18-2-1-7-30(18)19-6-9-31-21(28-19)17(11-26-31)27-22(33)29-8-5-14(32)12-29/h3-4,6,9-11,14,18,20,32H,1-2,5,7-8,12H2,(H,27,33)/t14-,18+/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars		n/a	n/a	8.70	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM136620 (US10005783, 37 | US10047097, 37 | US10774085, Exam...) Show SMILES O[C@H]1CCN(C1)C(=O)Nc1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1C(F)F |r| Show InChI InChI=1S/C22H23F3N6O2/c23-13-3-4-15(20(24)25)16(10-13)18-2-1-7-30(18)19-6-9-31-21(28-19)17(11-26-31)27-22(33)29-8-5-14(32)12-29/h3-4,6,9-11,14,18,20,32H,1-2,5,7-8,12H2,(H,27,33)/t14-,18+/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	8.70	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research					Assay Description Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...				Bioorg Med Chem 17: 7802-15 (2009) BindingDB Entry DOI: 10.7270/Q25H7JK7
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM136620 (US10005783, 37 | US10047097, 37 | US10774085, Exam...) Show SMILES O[C@H]1CCN(C1)C(=O)Nc1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1C(F)F |r| Show InChI InChI=1S/C22H23F3N6O2/c23-13-3-4-15(20(24)25)16(10-13)18-2-1-7-30(18)19-6-9-31-21(28-19)17(11-26-31)27-22(33)29-8-5-14(32)12-29/h3-4,6,9-11,14,18,20,32H,1-2,5,7-8,12H2,(H,27,33)/t14-,18+/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	8.70	n/a	n/a	n/a	n/a	n/a	n/a
ARRAY BIOPHARMA INC. US Patent					Assay Description An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...				US Patent US10774085 (2020)
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor [441-796] (Homo sapiens (Human))	BDBM136620 (US10005783, 37 | US10047097, 37 | US10774085, Exam...) Show SMILES O[C@H]1CCN(C1)C(=O)Nc1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1C(F)F |r| Show InChI InChI=1S/C22H23F3N6O2/c23-13-3-4-15(20(24)25)16(10-13)18-2-1-7-30(18)19-6-9-31-21(28-19)17(11-26-31)27-22(33)29-8-5-14(32)12-29/h3-4,6,9-11,14,18,20,32H,1-2,5,7-8,12H2,(H,27,33)/t14-,18+/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	8.70	n/a	n/a	n/a	n/a	7.5	n/a
Array BioPharma, Inc. US Patent					Assay Description Immulon 4HBX 384-well microtiter plates (Thermo part #8755) were coated with a 0.025 mg/mL solution of poly (Glu, Ala, Tyr; 6:3:1; Sigma P3899). Vari...				US Patent US9676783 (2017) BindingDB Entry DOI: 10.7270/Q26H4FK5
					More data for this Ligand-Target Pair