BDBM137319 US8871790, 405

SMILES: Cc1cc(C2CCC2)c(cc1C(=O)N1CCC(F)(CC1)c1ccc(cc1)C#N)-c1nc2CCOCc2[nH]1

InChI Key: InChIKey=KFUHWMREETWYEE-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 137319   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Fatty acid synthase (Homo sapiens (Human))	BDBM137319 (US8871790, 405) Show SMILES Cc1cc(C2CCC2)c(cc1C(=O)N1CCC(F)(CC1)c1ccc(cc1)C#N)-c1nc2CCOCc2[nH]1 Show InChI InChI=1S/C30H31FN4O2/c1-19-15-24(21-3-2-4-21)25(28-33-26-9-14-37-18-27(26)34-28)16-23(19)29(36)35-12-10-30(31,11-13-35)22-7-5-20(17-32)6-8-22/h5-8,15-16,21H,2-4,9-14,18H2,1H3,(H,33,34)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
3-V Biosciences, Inc. US Patent					Assay Description The FASN enzyme was isolated from SKBr3 cells. SKBr3 is a human breast cancer cell-line with high levels of FASN expression. It is estimated that FAS...				US Patent US8871790 (2014) BindingDB Entry DOI: 10.7270/Q2PG1QD3
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