BDBM13804 2-(3-aminopiperidin-1-yl)-1-[(2-cyanophenyl)methyl]-4-N,5-N-dimethyl-1H-imidazole-4,5-dicarboxamide::Xanthine mimetic compound 19
SMILES: CNC(=O)c1nc(N2CCCC(N)C2)n(Cc2ccccc2C#N)c1C(=O)NC
InChI Key: InChIKey=LHRRHKGNJMJPKU-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Dipeptidyl peptidase 4 (Homo sapiens (Human)) | BDBM13804 (2-(3-aminopiperidin-1-yl)-1-[(2-cyanophenyl)methyl...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 450 | -8.57 | n/a | n/a | n/a | n/a | n/a | 7.5 | 22 |
Abbott Laboratories | Assay Description The DPP activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 355 nm and meas... | Bioorg Med Chem Lett 16: 6226-30 (2006) Article DOI: 10.1016/j.bmcl.2006.09.024 BindingDB Entry DOI: 10.7270/Q2MP51H4 | |||||||||||
More data for this Ligand-Target Pair |