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SMILES: CN(C)CCCNc1ccc(cc1S(=O)(=O)C(F)(F)F)S(=O)(=O)NC(=O)c1csc(n1)N1CCc2cccc(C(=O)Nc3nc4ccccc4s3)c2C1

InChI Key: InChIKey=FAPQMEJNHQLEKU-UHFFFAOYSA-N

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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 139046   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Bcl-2-like protein 1


(Homo sapiens (Human))		BDBM139046
PNG
(US8883784, 7)
Show SMILES CN(C)CCCNc1ccc(cc1S(=O)(=O)C(F)(F)F)S(=O)(=O)NC(=O)c1csc(n1)N1CCc2cccc(C(=O)Nc3nc4ccccc4s3)c2C1
Show InChI InChI=1S/C33H32F3N7O6S4/c1-42(2)15-6-14-37-25-12-11-21(17-28(25)52(46,47)33(34,35)36)53(48,49)41-30(45)26-19-50-32(39-26)43-16-13-20-7-5-8-22(23(20)18-43)29(44)40-31-38-24-9-3-4-10-27(24)51-31/h3-5,7-12,17,19,37H,6,13-16,18H2,1-2H3,(H,41,45)(H,38,40,44)
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Similars
US Patent
 1.70 -12.0n/an/an/an/an/an/a25



AbbVie Inc.

US Patent


Assay Description
The measurement of competition of compounds of Formula (I) with F-Bak for a Bcl-2 family protein (Bcl-xL) binding site using a Time Resolved Fluoresc...

US Patent US8883784 (2014)


BindingDB Entry DOI: 10.7270/Q2GT5KWT
More data for this
Ligand-Target Pair