BDBM139258 US8614223, 34

SMILES: ONC(=O)c1cnc(NCc2cccc(Cl)c2)nc1

InChI Key: InChIKey=SFWOOCPEXAPROJ-UHFFFAOYSA-N

Data: 4 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 139258   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Histone deacetylase 1 (Homo sapiens (Human))	BDBM139258 (US8614223, 34) Show SMILES ONC(=O)c1cnc(NCc2cccc(Cl)c2)nc1 Show InChI InChI=1S/C12H11ClN4O2/c13-10-3-1-2-8(4-10)5-14-12-15-6-9(7-16-12)11(18)17-19/h1-4,6-7,19H,5H2,(H,17,18)(H,14,15,16)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	20	n/a	n/a	n/a	n/a	7.4	25
Acetylon Pharmaceuticals, Inc. US Patent					Assay Description Compounds for testing were diluted in DMSO to 50 fold the final concentration and a ten point three fold dilution series was made. The compounds were...				US Patent US8614223 (2013) BindingDB Entry DOI: 10.7270/Q2B27T00
					More data for this Ligand-Target Pair
Cereblon/Histone deacetylase 6 (Homo sapiens (Human))	BDBM139258 (US8614223, 34) Show SMILES ONC(=O)c1cnc(NCc2cccc(Cl)c2)nc1 Show InChI InChI=1S/C12H11ClN4O2/c13-10-3-1-2-8(4-10)5-14-12-15-6-9(7-16-12)11(18)17-19/h1-4,6-7,19H,5H2,(H,17,18)(H,14,15,16)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	7.4	25
Acetylon Pharmaceuticals, Inc. US Patent					Assay Description Compounds for testing were diluted in DMSO to 50 fold the final concentration and a ten point three fold dilution series was made. The compounds were...				US Patent US8614223 (2013) BindingDB Entry DOI: 10.7270/Q2B27T00
					More data for this Ligand-Target Pair
Histone deacetylase 3 (Homo sapiens (Human))	BDBM139258 (US8614223, 34) Show SMILES ONC(=O)c1cnc(NCc2cccc(Cl)c2)nc1 Show InChI InChI=1S/C12H11ClN4O2/c13-10-3-1-2-8(4-10)5-14-12-15-6-9(7-16-12)11(18)17-19/h1-4,6-7,19H,5H2,(H,17,18)(H,14,15,16)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	34	n/a	n/a	n/a	n/a	7.4	25
Acetylon Pharmaceuticals, Inc. US Patent					Assay Description Compounds for testing were diluted in DMSO to 50 fold the final concentration and a ten point three fold dilution series was made. The compounds were...				US Patent US8614223 (2013) BindingDB Entry DOI: 10.7270/Q2B27T00
					More data for this Ligand-Target Pair
Histone deacetylase 2 (Homo sapiens (Human))	BDBM139258 (US8614223, 34) Show SMILES ONC(=O)c1cnc(NCc2cccc(Cl)c2)nc1 Show InChI InChI=1S/C12H11ClN4O2/c13-10-3-1-2-8(4-10)5-14-12-15-6-9(7-16-12)11(18)17-19/h1-4,6-7,19H,5H2,(H,17,18)(H,14,15,16)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	28	n/a	n/a	n/a	n/a	7.4	25
Acetylon Pharmaceuticals, Inc. US Patent					Assay Description Compounds for testing were diluted in DMSO to 50 fold the final concentration and a ten point three fold dilution series was made. The compounds were...				US Patent US8614223 (2013) BindingDB Entry DOI: 10.7270/Q2B27T00
					More data for this Ligand-Target Pair