BDBM139818 US8895581, III-4

SMILES: CC(C)N1CCC(CC1)n1c(C)nc2cnc3ccc(cc3c12)C#CCNC(=O)c1ccnn(Cc2ccc(F)c(F)c2)c1=O

InChI Key: InChIKey=FVPDPNYHOQEPSB-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 139818   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
3-phosphoinositide-dependent protein kinase 1 (Homo sapiens (Human))	BDBM139818 (US8895581, III-4) Show SMILES CC(C)N1CCC(CC1)n1c(C)nc2cnc3ccc(cc3c12)C#CCNC(=O)c1ccnn(Cc2ccc(F)c(F)c2)c1=O Show InChI InChI=1S/C34H33F2N7O2/c1-21(2)41-15-11-25(12-16-41)43-22(3)40-31-19-38-30-9-7-23(17-27(30)32(31)43)5-4-13-37-33(44)26-10-14-39-42(34(26)45)20-24-6-8-28(35)29(36)18-24/h6-10,14,17-19,21,25H,11-13,15-16,20H2,1-3H3,(H,37,44)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	21	n/a	n/a	n/a	n/a	7.5	n/a
Boehringer Ingelheim International GmbH US Patent					Assay Description Recombinant human PDK1 enzyme (aa 52-556) linked at its N-terminal end to His6 is isolated from baculovirus-infected insect cells. Purified enzyme ma...				US Patent US8895581 (2014) BindingDB Entry DOI: 10.7270/Q2HM5742
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