BDBM139991 US8901140, 5::US9358227, 5
SMILES: CCOc1cc2ncc(C#N)c(Nc3ccc(OCc4ccccn4)c(Cl)c3)c2cc1NC(=O)\C=C\[C@H]1CCCN1C
InChI Key: InChIKey=SADXACCFNXBCFY-IYNHSRRRSA-N
Data: 3 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Epidermal growth factor receptor (Homo sapiens (Human)) | BDBM139991 (US8901140, 5 | US9358227, 5) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | n/a |
Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd. US Patent | Assay Description The following assay may be used to determine the activity of the compounds of the invention for inhibiting EGFR kinase activity. The half maximal inh... | US Patent US8901140 (2014) BindingDB Entry DOI: 10.7270/Q2VX0F76 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Epidermal growth factor receptor (Homo sapiens (Human)) | BDBM139991 (US8901140, 5 | US9358227, 5) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | n/a |
Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd. US Patent | Assay Description The following assay may be used to determine the activity of the compounds of the invention for inhibiting EGFR kinase activity. The half maximal inh... | US Patent US9358227 (2016) BindingDB Entry DOI: 10.7270/Q2RJ4HB5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Epidermal growth factor receptor (Homo sapiens (Human)) | BDBM139991 (US8901140, 5 | US9358227, 5) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 45 | n/a | n/a | n/a | n/a | n/a | n/a |
Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd. US Patent | Assay Description The following in vitro assay is to determine the activity of the tested compounds for inhibiting the proliferation of cancer cells, which has high ex... | US Patent US9358227 (2016) BindingDB Entry DOI: 10.7270/Q2RJ4HB5 | |||||||||||
More data for this Ligand-Target Pair |