BDBM140142 US8901315, 275

SMILES: CN1CC(=O)N([C@H]2CC[C@@H](CC2)NC(=O)c2cc3c(C)nn(C4CCCCC4)c3s2)C1=O

InChI Key: InChIKey=FWFSPWJEERLPRD-WKILWMFISA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 140142   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Phosphodiesterase 4 (PDE4) (Mus musculus (Mouse))	BDBM140142 (US8901315, 275) Show SMILES CN1CC(=O)N([C@H]2CC[C@@H](CC2)NC(=O)c2cc3c(C)nn(C4CCCCC4)c3s2)C1=O |r,wU:9.12,wD:6.5,(9.15,.69,;7.81,1.46,;7.81,3,;6.35,3.48,;5.58,4.81,;5.44,2.23,;3.9,2.23,;3.13,3.56,;1.59,3.56,;.82,2.23,;1.59,.9,;3.13,.9,;-.72,2.23,;-1.49,.9,;-.72,-.44,;-3.03,.9,;-3.93,2.14,;-5.4,1.67,;-6.86,2.14,;-7.63,3.48,;-7.77,.9,;-6.86,-.35,;-7.26,-1.84,;-8.75,-2.23,;-9.15,-3.72,;-8.06,-4.81,;-6.57,-4.41,;-6.17,-2.92,;-5.4,.13,;-3.93,-.35,;6.35,.99,;5.58,-.35,)| Show InChI InChI=1S/C23H31N5O3S/c1-14-18-12-19(32-22(18)28(25-14)17-6-4-3-5-7-17)21(30)24-15-8-10-16(11-9-15)27-20(29)13-26(2)23(27)31/h12,15-17H,3-11,13H2,1-2H3,(H,24,30)/t15-,16-	PDB KEGG UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.20E+3	n/a	n/a	n/a	n/a	6.5	4
Daiichi Sankyo Company, Limited US Patent					Assay Description The PDE 4 (phosphodiesterase IV) inhibiting effect of the compounds of the present invention was performed by the following method, which was modifie...				US Patent US8901315 (2014) BindingDB Entry DOI: 10.7270/Q2GM860P
					More data for this Ligand-Target Pair
Phosphodiesterase 7 (Homo sapiens (Human))	BDBM140142 (US8901315, 275) Show SMILES CN1CC(=O)N([C@H]2CC[C@@H](CC2)NC(=O)c2cc3c(C)nn(C4CCCCC4)c3s2)C1=O |r,wU:9.12,wD:6.5,(9.15,.69,;7.81,1.46,;7.81,3,;6.35,3.48,;5.58,4.81,;5.44,2.23,;3.9,2.23,;3.13,3.56,;1.59,3.56,;.82,2.23,;1.59,.9,;3.13,.9,;-.72,2.23,;-1.49,.9,;-.72,-.44,;-3.03,.9,;-3.93,2.14,;-5.4,1.67,;-6.86,2.14,;-7.63,3.48,;-7.77,.9,;-6.86,-.35,;-7.26,-1.84,;-8.75,-2.23,;-9.15,-3.72,;-8.06,-4.81,;-6.57,-4.41,;-6.17,-2.92,;-5.4,.13,;-3.93,-.35,;6.35,.99,;5.58,-.35,)| Show InChI InChI=1S/C23H31N5O3S/c1-14-18-12-19(32-22(18)28(25-14)17-6-4-3-5-7-17)21(30)24-15-8-10-16(11-9-15)27-20(29)13-26(2)23(27)31/h12,15-17H,3-11,13H2,1-2H3,(H,24,30)/t15-,16-	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	4	n/a	n/a	n/a	n/a	7.5	4
Daiichi Sankyo Company, Limited US Patent					Assay Description The PDE 7 (phosphodiesterase VII) inhibiting effect of the compounds of the present invention was performed by the following method, which was modifi...				US Patent US8901315 (2014) BindingDB Entry DOI: 10.7270/Q2GM860P
					More data for this Ligand-Target Pair