BDBM140229 US8906911, 38

SMILES: CO[C@@H]1COCC[C@@H]1N[C@@H]1C[C@H]2CCC[C@]2(C1)C(=O)N1C[C@@H]2C[C@H]1CN2c1nccc(c1C)C(F)(F)F

InChI Key: InChIKey=ULFCMIBDLVQYRA-SIRCMURCSA-N

Data: 1 IC50

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Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 140229   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
C-C chemokine receptor type 2 (Homo sapiens (Human))	BDBM140229 (US8906911, 38) Show SMILES CO[C@@H]1COCC[C@@H]1N[C@@H]1C[C@H]2CCC[C@]2(C1)C(=O)N1C[C@@H]2C[C@H]1CN2c1nccc(c1C)C(F)(F)F |r| Show InChI InChI=1S/C27H37F3N4O3/c1-16-21(27(28,29)30)5-8-31-24(16)33-13-20-11-19(33)14-34(20)25(35)26-7-3-4-17(26)10-18(12-26)32-22-6-9-37-15-23(22)36-2/h5,8,17-20,22-23,32H,3-4,6-7,9-15H2,1-2H3/t17-,18-,19+,20+,22+,23-,26-/m1/s1	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.60E+3	n/a	n/a	n/a	n/a	7.4	4
AbbVie Inc. US Patent					Assay Description Radioligand binding assays were performed in CHO cells expressing human CCR2B and Galpha±16 coupling protein. All compounds were dissolved in DMSO a...				US Patent US8906911 (2014) BindingDB Entry DOI: 10.7270/Q2BV7FBV
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