BDBM140255 US8906911, 64

SMILES: C[C@@H]1COCC[C@H]1N[C@@H]1C[C@H]2CCC[C@]2(C1)C(=O)N1C[C@@H]2C[C@H]1CN2c1cc(ccn1)C(F)(F)F

InChI Key: InChIKey=PQOVWDIJLRLJSN-VVBYYNAWSA-N

Data: 1 KI  1 IC50

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Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 140255   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
C-C chemokine receptor type 2 (Homo sapiens (Human))	BDBM140255 (US8906911, 64) Show SMILES C[C@@H]1COCC[C@H]1N[C@@H]1C[C@H]2CCC[C@]2(C1)C(=O)N1C[C@@H]2C[C@H]1CN2c1cc(ccn1)C(F)(F)F |r| Show InChI InChI=1S/C26H35F3N4O2/c1-16-15-35-8-5-22(16)31-19-9-17-3-2-6-25(17,12-19)24(34)33-14-20-11-21(33)13-32(20)23-10-18(4-7-30-23)26(27,28)29/h4,7,10,16-17,19-22,31H,2-3,5-6,8-9,11-15H2,1H3/t16-,17-,19-,20+,21+,22-,25-/m1/s1	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	12	-10.0	16.5	n/a	n/a	n/a	n/a	7.4	4
AbbVie Inc. US Patent					Assay Description Radioligand binding assays were performed in CHO cells expressing human CCR2B and Galpha±16 coupling protein. All compounds were dissolved in DMSO a...				US Patent US8906911 (2014) BindingDB Entry DOI: 10.7270/Q2BV7FBV
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