BDBM140329 US8912173, 55

SMILES: C[C@@H](Oc1cc(cc2ncccc12)-c1ccc(CN2CCCCC2=O)cc1)[C@H]1CNC(=O)C1

InChI Key: InChIKey=YMONIRJSSYFYAT-XMSQKQJNSA-N

Data: 1 IC50

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Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 140329   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM140329 (US8912173, 55) Show SMILES C[C@@H](Oc1cc(cc2ncccc12)-c1ccc(CN2CCCCC2=O)cc1)[C@H]1CNC(=O)C1 |r| Show InChI InChI=1S/C27H29N3O3/c1-18(22-15-26(31)29-16-22)33-25-14-21(13-24-23(25)5-4-11-28-24)20-9-7-19(8-10-20)17-30-12-3-2-6-27(30)32/h4-5,7-11,13-14,18,22H,2-3,6,12,15-17H2,1H3,(H,29,31)/t18-,22-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.300	n/a	n/a	n/a	n/a	7.5	-80
Boehringer Ingelheim International GmbH US Patent					Assay Description Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...				US Patent US8912173 (2014) BindingDB Entry DOI: 10.7270/Q2TX3D3T
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