BDBM140337 US8912173, 63

SMILES: C[C@@H](Oc1cc(cc2ncccc12)-c1ccc2NC(=O)OCc2c1)[C@H]1CNC(=O)C1

InChI Key: InChIKey=OBWXJXCCRUFOHL-CZUORRHYSA-N

Data: 1 IC50

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Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 140337   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM140337 (US8912173, 63) Show SMILES C[C@@H](Oc1cc(cc2ncccc12)-c1ccc2NC(=O)OCc2c1)[C@H]1CNC(=O)C1 |r| Show InChI InChI=1S/C23H21N3O4/c1-13(16-10-22(27)25-11-16)30-21-9-15(8-20-18(21)3-2-6-24-20)14-4-5-19-17(7-14)12-29-23(28)26-19/h2-9,13,16H,10-12H2,1H3,(H,25,27)(H,26,28)/t13-,16-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.100	n/a	n/a	n/a	n/a	7.5	-80
Boehringer Ingelheim International GmbH US Patent					Assay Description Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...				US Patent US8912173 (2014) BindingDB Entry DOI: 10.7270/Q2TX3D3T
					More data for this Ligand-Target Pair