null

SMILES: CCCC(=O)Nc1cccc(c1)-c1nc(Nc2ccc3[nH]ncc3c2)c2cc(OCCOC)c(OC)cc2n1

InChI Key: InChIKey=RBMZTABDHRMSMI-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 141003   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Rho-associated protein kinase 2 (Homo sapiens (Human))	BDBM141003 (US10570123, Example 207 | US8916576, 207) Show SMILES CCCC(=O)Nc1cccc(c1)-c1nc(Nc2ccc3[nH]ncc3c2)c2cc(OCCOC)c(OC)cc2n1 Show InChI InChI=1S/C29H30N6O4/c1-4-6-27(36)31-20-8-5-7-18(13-20)28-33-24-16-25(38-3)26(39-12-11-37-2)15-22(24)29(34-28)32-21-9-10-23-19(14-21)17-30-35-23/h5,7-10,13-17H,4,6,11-12H2,1-3H3,(H,30,35)(H,31,36)(H,32,33,34)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	61	n/a	n/a	n/a	n/a	n/a	n/a
Surface Logix, Inc. US Patent					Assay Description ROCK-II inhibitory activity can be measured using the ROCK-II Assay Kit (Molecular Devices, inc.; Sunnyvale, Calif.).				US Patent US8916576 (2014) BindingDB Entry DOI: 10.7270/Q2P55M6K
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 (Homo sapiens (Human))	BDBM141003 (US10570123, Example 207 | US8916576, 207) Show SMILES CCCC(=O)Nc1cccc(c1)-c1nc(Nc2ccc3[nH]ncc3c2)c2cc(OCCOC)c(OC)cc2n1 Show InChI InChI=1S/C29H30N6O4/c1-4-6-27(36)31-20-8-5-7-18(13-20)28-33-24-16-25(38-3)26(39-12-11-37-2)15-22(24)29(34-28)32-21-9-10-23-19(14-21)17-30-35-23/h5,7-10,13-17H,4,6,11-12H2,1-3H3,(H,30,35)(H,31,36)(H,32,33,34)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	44	n/a	n/a	n/a	n/a	n/a	n/a
Surface Logix, Inc. US Patent					Assay Description ROCK-II inhibitory activity can be measured using the ROCK-II Assay Kit (Molecular Devices, inc.; Sunnyvale, Calif.).				US Patent US8916576 (2014) BindingDB Entry DOI: 10.7270/Q2P55M6K
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 (Homo sapiens (Human))	BDBM141003 (US10570123, Example 207 | US8916576, 207) Show SMILES CCCC(=O)Nc1cccc(c1)-c1nc(Nc2ccc3[nH]ncc3c2)c2cc(OCCOC)c(OC)cc2n1 Show InChI InChI=1S/C29H30N6O4/c1-4-6-27(36)31-20-8-5-7-18(13-20)28-33-24-16-25(38-3)26(39-12-11-37-2)15-22(24)29(34-28)32-21-9-10-23-19(14-21)17-30-35-23/h5,7-10,13-17H,4,6,11-12H2,1-3H3,(H,30,35)(H,31,36)(H,32,33,34)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	29	n/a	n/a	n/a	n/a	n/a	n/a
SURFACE LOGIX, LLC US Patent					Assay Description ROCK-II inhibitory activity can be measured using the ROCK-II Assay Kit (Molecular Devices, inc.; Sunnyvale, Calif.).				US Patent US10570123 (2020) BindingDB Entry DOI: 10.7270/Q2542R1V
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 (Homo sapiens (Human))	BDBM141003 (US10570123, Example 207 | US8916576, 207) Show SMILES CCCC(=O)Nc1cccc(c1)-c1nc(Nc2ccc3[nH]ncc3c2)c2cc(OCCOC)c(OC)cc2n1 Show InChI InChI=1S/C29H30N6O4/c1-4-6-27(36)31-20-8-5-7-18(13-20)28-33-24-16-25(38-3)26(39-12-11-37-2)15-22(24)29(34-28)32-21-9-10-23-19(14-21)17-30-35-23/h5,7-10,13-17H,4,6,11-12H2,1-3H3,(H,30,35)(H,31,36)(H,32,33,34)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	61	n/a	n/a	n/a	n/a	n/a	n/a
SURFACE LOGIX, LLC US Patent					Assay Description ROCK-II inhibitory activity can be measured using the ROCK-II Assay Kit (Molecular Devices, inc.; Sunnyvale, Calif.).				US Patent US10570123 (2020) BindingDB Entry DOI: 10.7270/Q2542R1V
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 (Homo sapiens (Human))	BDBM141003 (US10570123, Example 207 | US8916576, 207) Show SMILES CCCC(=O)Nc1cccc(c1)-c1nc(Nc2ccc3[nH]ncc3c2)c2cc(OCCOC)c(OC)cc2n1 Show InChI InChI=1S/C29H30N6O4/c1-4-6-27(36)31-20-8-5-7-18(13-20)28-33-24-16-25(38-3)26(39-12-11-37-2)15-22(24)29(34-28)32-21-9-10-23-19(14-21)17-30-35-23/h5,7-10,13-17H,4,6,11-12H2,1-3H3,(H,30,35)(H,31,36)(H,32,33,34)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	29	n/a	n/a	n/a	n/a	n/a	n/a
SURFACE LOGIX, LLC US Patent					Assay Description ROCK-II inhibitory activity can be measured using the ROCK-II Assay Kit (Molecular Devices, inc.; Sunnyvale, Calif.).				US Patent US10570123 (2020) BindingDB Entry DOI: 10.7270/Q2542R1V
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 (Homo sapiens (Human))	BDBM141003 (US10570123, Example 207 | US8916576, 207) Show SMILES CCCC(=O)Nc1cccc(c1)-c1nc(Nc2ccc3[nH]ncc3c2)c2cc(OCCOC)c(OC)cc2n1 Show InChI InChI=1S/C29H30N6O4/c1-4-6-27(36)31-20-8-5-7-18(13-20)28-33-24-16-25(38-3)26(39-12-11-37-2)15-22(24)29(34-28)32-21-9-10-23-19(14-21)17-30-35-23/h5,7-10,13-17H,4,6,11-12H2,1-3H3,(H,30,35)(H,31,36)(H,32,33,34)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	29	n/a	n/a	n/a	n/a	n/a	n/a
Surface Logix, Inc. US Patent					Assay Description ROCK-II inhibitory activity can be measured using the ROCK-II Assay Kit (Molecular Devices, inc.; Sunnyvale, Calif.).				US Patent US8916576 (2014) BindingDB Entry DOI: 10.7270/Q2P55M6K
					More data for this Ligand-Target Pair