BDBM141398 US10668051, Compound Example 16::US8921364, 16

SMILES: Fc1cnccc1C(=O)Nc1ccc(cc1)-n1nc(cc1C1CC1)C1CC1

InChI Key: InChIKey=ZGOGOEHAPKNVDW-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 141398   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Calcium release-activated calcium channel protein 1 (Homo sapiens (Human))	BDBM141398 (US10668051, Compound Example 16 | US8921364, 16) Show SMILES Fc1cnccc1C(=O)Nc1ccc(cc1)-n1nc(cc1C1CC1)C1CC1 Show InChI InChI=1S/C21H19FN4O/c22-18-12-23-10-9-17(18)21(27)24-15-5-7-16(8-6-15)26-20(14-3-4-14)11-19(25-26)13-1-2-13/h5-14H,1-4H2,(H,24,27)	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	244	n/a	n/a	n/a	n/a	n/a	n/a
RHIZEN PHARMACEUTICALS SA US Patent					Assay Description Inhibition of CRAC channels was determined following thapsigargin (Sigma, Cat #T9033) induced endoplasmic calcium release in Jurkat cells, (see Yasur...				US Patent US10668051 (2020)
					More data for this Ligand-Target Pair
EF-hand calcium-binding domain-containing protein 4B (Homo sapiens (Human))	BDBM141398 (US10668051, Compound Example 16 | US8921364, 16) Show SMILES Fc1cnccc1C(=O)Nc1ccc(cc1)-n1nc(cc1C1CC1)C1CC1 Show InChI InChI=1S/C21H19FN4O/c22-18-12-23-10-9-17(18)21(27)24-15-5-7-16(8-6-15)26-20(14-3-4-14)11-19(25-26)13-1-2-13/h5-14H,1-4H2,(H,24,27)	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	244	n/a	n/a	n/a	n/a	n/a	37
Rhizen Pharmaceuticals SA US Patent					Assay Description Inhibition of CRAC channels was determined following thapsigargin (Sigma, Cat # T9033) induced endoplasmic calcium release in Jurkat cells. (see Yasu...				US Patent US8921364 (2014) BindingDB Entry DOI: 10.7270/Q2N58K3N
					More data for this Ligand-Target Pair