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SMILES: Cc1ncsc1CNc1ccc(cc1)-n1nc(cc1C1CC1)C(F)(F)F

InChI Key: InChIKey=MYWRMJZQVRBGIM-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 141419   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Calcium release-activated calcium channel protein 1 (Homo sapiens (Human))	BDBM141419 (US10668051, Compound Example 74 | US8921364, 74) Show SMILES Cc1ncsc1CNc1ccc(cc1)-n1nc(cc1C1CC1)C(F)(F)F Show InChI InChI=1S/C18H17F3N4S/c1-11-16(26-10-23-11)9-22-13-4-6-14(7-5-13)25-15(12-2-3-12)8-17(24-25)18(19,20)21/h4-8,10,12,22H,2-3,9H2,1H3	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	48	n/a	n/a	n/a	n/a	n/a	n/a
RHIZEN PHARMACEUTICALS SA US Patent					Assay Description Inhibition of CRAC channels was determined following thapsigargin (Sigma, Cat #T9033) induced endoplasmic calcium release in Jurkat cells, (see Yasur...				US Patent US10668051 (2020)
					More data for this Ligand-Target Pair
EF-hand calcium-binding domain-containing protein 4B (Homo sapiens (Human))	BDBM141419 (US10668051, Compound Example 74 | US8921364, 74) Show SMILES Cc1ncsc1CNc1ccc(cc1)-n1nc(cc1C1CC1)C(F)(F)F Show InChI InChI=1S/C18H17F3N4S/c1-11-16(26-10-23-11)9-22-13-4-6-14(7-5-13)25-15(12-2-3-12)8-17(24-25)18(19,20)21/h4-8,10,12,22H,2-3,9H2,1H3	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	48.0	n/a	n/a	n/a	n/a	n/a	37
Rhizen Pharmaceuticals SA US Patent					Assay Description Inhibition of CRAC channels was determined following thapsigargin (Sigma, Cat # T9033) induced endoplasmic calcium release in Jurkat cells. (see Yasu...				US Patent US8921364 (2014) BindingDB Entry DOI: 10.7270/Q2N58K3N
					More data for this Ligand-Target Pair