null

SMILES: Fc1cccc(F)c1C(=O)Nc1cnc(nc1)-n1nc(cc1C1CC1)C(F)(F)F

InChI Key: InChIKey=OLBVHWVLKVATBM-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 141446   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Calcium release-activated calcium channel protein 1 (Homo sapiens (Human))	BDBM141446 (US10668051, Compound Example 124 | US8921364, 124) Show SMILES Fc1cccc(F)c1C(=O)Nc1cnc(nc1)-n1nc(cc1C1CC1)C(F)(F)F Show InChI InChI=1S/C18H12F5N5O/c19-11-2-1-3-12(20)15(11)16(29)26-10-7-24-17(25-8-10)28-13(9-4-5-9)6-14(27-28)18(21,22)23/h1-3,6-9H,4-5H2,(H,26,29)	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	295	n/a	n/a	n/a	n/a	n/a	n/a
RHIZEN PHARMACEUTICALS SA US Patent					Assay Description Inhibition of CRAC channels was determined following thapsigargin (Sigma, Cat #T9033) induced endoplasmic calcium release in Jurkat cells, (see Yasur...				US Patent US10668051 (2020) BindingDB Entry DOI: 10.7270/Q2V40Z7G
					More data for this Ligand-Target Pair
EF-hand calcium-binding domain-containing protein 4B (Homo sapiens (Human))	BDBM141446 (US10668051, Compound Example 124 | US8921364, 124) Show SMILES Fc1cccc(F)c1C(=O)Nc1cnc(nc1)-n1nc(cc1C1CC1)C(F)(F)F Show InChI InChI=1S/C18H12F5N5O/c19-11-2-1-3-12(20)15(11)16(29)26-10-7-24-17(25-8-10)28-13(9-4-5-9)6-14(27-28)18(21,22)23/h1-3,6-9H,4-5H2,(H,26,29)	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	295	n/a	n/a	n/a	n/a	n/a	37
Rhizen Pharmaceuticals SA US Patent					Assay Description Inhibition of CRAC channels was determined following thapsigargin (Sigma, Cat # T9033) induced endoplasmic calcium release in Jurkat cells. (see Yasu...				US Patent US8921364 (2014) BindingDB Entry DOI: 10.7270/Q2N58K3N
					More data for this Ligand-Target Pair