null

SMILES: CC1(C)[C@@H](CC[C@]1(C)NS(C)(=O)=O)Nc1c(cnn2cc(cc12)-c1ccccc1)C(N)=O

InChI Key: InChIKey=AWCUIJQFLVDGFM-XXBNENTESA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 141460   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase JAK1 (Homo sapiens (Human))	BDBM141460 (US8921368, 129) Show SMILES CC1(C)[C@@H](CC[C@]1(C)NS(C)(=O)=O)Nc1c(cnn2cc(cc12)-c1ccccc1)C(N)=O |r| Show InChI InChI=1S/C23H29N5O3S/c1-22(2)19(10-11-23(22,3)27-32(4,30)31)26-20-17(21(24)29)13-25-28-14-16(12-18(20)28)15-8-6-5-7-9-15/h5-9,12-14,19,26-27H,10-11H2,1-4H3,(H2,24,29)/t19-,23+/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	2.60	n/a	n/a	n/a	n/a	7.4	25
Bristol-Myers Squibb Company US Patent					Assay Description The assay reactions were performed in U-bottom 384-well plates. The final assay volume was 30 ul prepared from 15 ul additions of enzyme and substr...				US Patent US8921368 (2014) BindingDB Entry DOI: 10.7270/Q2HH6HS7
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 (Homo sapiens (Human))	BDBM141460 (US8921368, 129) Show SMILES CC1(C)[C@@H](CC[C@]1(C)NS(C)(=O)=O)Nc1c(cnn2cc(cc12)-c1ccccc1)C(N)=O |r| Show InChI InChI=1S/C23H29N5O3S/c1-22(2)19(10-11-23(22,3)27-32(4,30)31)26-20-17(21(24)29)13-25-28-14-16(12-18(20)28)15-8-6-5-7-9-15/h5-9,12-14,19,26-27H,10-11H2,1-4H3,(H2,24,29)/t19-,23+/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	8.0	25
Bristol-Myers Squibb Company US Patent					Assay Description Kinase reactions consisted of 5 ng of JAK3 enzyme, 30 uM CSKtide substrate, 0.2 uCi gamma-33P ATP, 8 uM ATP in 30 ul kinase buffer (50 mM Hepes, pH ...				US Patent US8921368 (2014) BindingDB Entry DOI: 10.7270/Q2HH6HS7
					More data for this Ligand-Target Pair