null

SMILES: Cn1nccc1-c1cc2c(N[C@@H]3CC[C@](C)(O)C3(C)C)c(cnn2c1)C(N)=O

InChI Key: InChIKey=RXPSHRJIOZEJRY-UZLBHIALSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 141462   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase JAK1 (Homo sapiens (Human))	BDBM141462 (US8921368, 148) Show SMILES Cn1nccc1-c1cc2c(N[C@@H]3CC[C@](C)(O)C3(C)C)c(cnn2c1)C(N)=O |r| Show InChI InChI=1S/C20H26N6O2/c1-19(2)16(5-7-20(19,3)28)24-17-13(18(21)27)10-23-26-11-12(9-15(17)26)14-6-8-22-25(14)4/h6,8-11,16,24,28H,5,7H2,1-4H3,(H2,21,27)/t16-,20+/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	46.4	n/a	n/a	n/a	n/a	7.4	25
Bristol-Myers Squibb Company US Patent					Assay Description The assay reactions were performed in U-bottom 384-well plates. The final assay volume was 30 ul prepared from 15 ul additions of enzyme and substr...				US Patent US8921368 (2014) BindingDB Entry DOI: 10.7270/Q2HH6HS7
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 (Homo sapiens (Human))	BDBM141462 (US8921368, 148) Show SMILES Cn1nccc1-c1cc2c(N[C@@H]3CC[C@](C)(O)C3(C)C)c(cnn2c1)C(N)=O |r| Show InChI InChI=1S/C20H26N6O2/c1-19(2)16(5-7-20(19,3)28)24-17-13(18(21)27)10-23-26-11-12(9-15(17)26)14-6-8-22-25(14)4/h6,8-11,16,24,28H,5,7H2,1-4H3,(H2,21,27)/t16-,20+/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	25.2	n/a	n/a	n/a	n/a	8.0	25
Bristol-Myers Squibb Company US Patent					Assay Description Kinase reactions consisted of 5 ng of JAK3 enzyme, 30 uM CSKtide substrate, 0.2 uCi gamma-33P ATP, 8 uM ATP in 30 ul kinase buffer (50 mM Hepes, pH ...				US Patent US8921368 (2014) BindingDB Entry DOI: 10.7270/Q2HH6HS7
					More data for this Ligand-Target Pair