BDBM141467 US8921368, 168

SMILES: C[C@@]1(O)CC[C@@H](CC1)Nc1c(cnn2cc(cc12)-c1cncnc1)C(N)=O

InChI Key: InChIKey=SWNPBOPZUAINOD-DHFPXDALSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 141467   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase JAK1 (Homo sapiens (Human))	BDBM141467 (US8921368, 168) Show SMILES C[C@@]1(O)CC[C@@H](CC1)Nc1c(cnn2cc(cc12)-c1cncnc1)C(N)=O |r,wU:5.8,1.1,wD:1.0,(-3.17,3.47,;-1.84,2.69,;-1.84,4.23,;-1.84,1.15,;-.51,.38,;.83,1.15,;.83,2.69,;-.51,3.47,;2.16,.38,;2.16,-1.15,;3.49,-1.93,;3.49,-3.47,;2.16,-4.23,;.83,-3.47,;-.64,-3.94,;-1.54,-2.69,;-.64,-1.45,;.83,-1.93,;-3.08,-2.69,;-3.85,-1.36,;-5.39,-1.36,;-6.16,-2.69,;-5.39,-4.03,;-3.85,-4.03,;4.83,-1.15,;6.16,-1.93,;4.83,.38,)| Show InChI InChI=1S/C19H22N6O2/c1-19(27)4-2-14(3-5-19)24-17-15(18(20)26)9-23-25-10-12(6-16(17)25)13-7-21-11-22-8-13/h6-11,14,24,27H,2-5H2,1H3,(H2,20,26)/t14-,19+	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	105	n/a	n/a	n/a	n/a	7.4	25
Bristol-Myers Squibb Company US Patent					Assay Description The assay reactions were performed in U-bottom 384-well plates. The final assay volume was 30 ul prepared from 15 ul additions of enzyme and substr...				US Patent US8921368 (2014) BindingDB Entry DOI: 10.7270/Q2HH6HS7
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 (Homo sapiens (Human))	BDBM141467 (US8921368, 168) Show SMILES C[C@@]1(O)CC[C@@H](CC1)Nc1c(cnn2cc(cc12)-c1cncnc1)C(N)=O |r,wU:5.8,1.1,wD:1.0,(-3.17,3.47,;-1.84,2.69,;-1.84,4.23,;-1.84,1.15,;-.51,.38,;.83,1.15,;.83,2.69,;-.51,3.47,;2.16,.38,;2.16,-1.15,;3.49,-1.93,;3.49,-3.47,;2.16,-4.23,;.83,-3.47,;-.64,-3.94,;-1.54,-2.69,;-.64,-1.45,;.83,-1.93,;-3.08,-2.69,;-3.85,-1.36,;-5.39,-1.36,;-6.16,-2.69,;-5.39,-4.03,;-3.85,-4.03,;4.83,-1.15,;6.16,-1.93,;4.83,.38,)| Show InChI InChI=1S/C19H22N6O2/c1-19(27)4-2-14(3-5-19)24-17-15(18(20)26)9-23-25-10-12(6-16(17)25)13-7-21-11-22-8-13/h6-11,14,24,27H,2-5H2,1H3,(H2,20,26)/t14-,19+	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	17.1	n/a	n/a	n/a	n/a	8.0	25
Bristol-Myers Squibb Company US Patent					Assay Description Kinase reactions consisted of 5 ng of JAK3 enzyme, 30 uM CSKtide substrate, 0.2 uCi gamma-33P ATP, 8 uM ATP in 30 ul kinase buffer (50 mM Hepes, pH ...				US Patent US8921368 (2014) BindingDB Entry DOI: 10.7270/Q2HH6HS7
					More data for this Ligand-Target Pair