null

SMILES: Cn1nccc1-c1cc2c(NC3C4CC5CC3CC(O)(C5)C4)c(cnn2c1)C(N)=O

InChI Key: InChIKey=NSFJTWRJSMPSRY-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 141471   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase JAK3 (Homo sapiens (Human))	BDBM141471 (US8921368, 185) Show SMILES Cn1nccc1-c1cc2c(NC3C4CC5CC3CC(O)(C5)C4)c(cnn2c1)C(N)=O |TLB:19:18:11:13.14.15,10:11:13:18.20.21,10:11:18.17.21:13.14.15,THB:20:18:11:13.14.15,20:14:11:18.17.21,17:18:13:11.16.15,17:16:13:18.20.21,(-3.57,-5.32,;-4.34,-3.99,;-5.81,-3.51,;-5.81,-1.97,;-4.34,-1.49,;-3.44,-2.74,;-1.9,-2.74,;-.99,-1.49,;.47,-1.97,;1.81,-1.2,;1.81,.34,;.47,1.11,;-.36,3.01,;-.36,4.55,;-1.69,5.32,;-.94,4.15,;-.92,1.75,;-2.13,1.09,;-3.02,3.01,;-4.36,2.24,;-3.02,4.55,;-1.69,2.24,;3.14,-1.97,;3.14,-3.51,;1.81,-4.28,;.47,-3.51,;-.99,-3.99,;4.47,-1.2,;5.81,-1.97,;4.47,.34,)| Show InChI InChI=1S/C22H26N6O2/c1-27-17(2-3-24-27)15-6-18-20(16(21(23)29)10-25-28(18)11-15)26-19-13-4-12-5-14(19)9-22(30,7-12)8-13/h2-3,6,10-14,19,26,30H,4-5,7-9H2,1H3,(H2,23,29)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	6.20	n/a	n/a	n/a	n/a	8.0	25
Bristol-Myers Squibb Company US Patent					Assay Description Kinase reactions consisted of 5 ng of JAK3 enzyme, 30 uM CSKtide substrate, 0.2 uCi gamma-33P ATP, 8 uM ATP in 30 ul kinase buffer (50 mM Hepes, pH ...				US Patent US8921368 (2014) BindingDB Entry DOI: 10.7270/Q2HH6HS7
					More data for this Ligand-Target Pair