BDBM141493 US8921368, 318

SMILES: C[C@]1(F)CCC[C@H]1Nc1c(cnn2cc(cc12)N1CCOCC1=O)C(N)=O

InChI Key: InChIKey=UBBBQOKSQMRKSL-KDOFPFPSSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 141493   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase JAK1 (Homo sapiens (Human))	BDBM141493 (US8921368, 318) Show SMILES C[C@]1(F)CCC[C@H]1Nc1c(cnn2cc(cc12)N1CCOCC1=O)C(N)=O |r| Show InChI InChI=1S/C18H22FN5O3/c1-18(19)4-2-3-14(18)22-16-12(17(20)26)8-21-24-9-11(7-13(16)24)23-5-6-27-10-15(23)25/h7-9,14,22H,2-6,10H2,1H3,(H2,20,26)/t14-,18+/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	13.4	n/a	n/a	n/a	n/a	7.4	25
Bristol-Myers Squibb Company US Patent					Assay Description The assay reactions were performed in U-bottom 384-well plates. The final assay volume was 30 ul prepared from 15 ul additions of enzyme and substr...				US Patent US8921368 (2014) BindingDB Entry DOI: 10.7270/Q2HH6HS7
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 (Homo sapiens (Human))	BDBM141493 (US8921368, 318) Show SMILES C[C@]1(F)CCC[C@H]1Nc1c(cnn2cc(cc12)N1CCOCC1=O)C(N)=O |r| Show InChI InChI=1S/C18H22FN5O3/c1-18(19)4-2-3-14(18)22-16-12(17(20)26)8-21-24-9-11(7-13(16)24)23-5-6-27-10-15(23)25/h7-9,14,22H,2-6,10H2,1H3,(H2,20,26)/t14-,18+/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	7.10	n/a	n/a	n/a	n/a	8.0	25
Bristol-Myers Squibb Company US Patent					Assay Description Kinase reactions consisted of 5 ng of JAK3 enzyme, 30 uM CSKtide substrate, 0.2 uCi gamma-33P ATP, 8 uM ATP in 30 ul kinase buffer (50 mM Hepes, pH ...				US Patent US8921368 (2014) BindingDB Entry DOI: 10.7270/Q2HH6HS7
					More data for this Ligand-Target Pair