null

SMILES: Cc1csc(n1)C(=O)NC12CCC(C1)(CCC2)C(=O)Nc1cccc(C)n1

InChI Key: InChIKey=QJFJDPVDKZVXJG-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 141508   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Glutamate receptor ionotropic, kainate 1 (Homo sapiens (Human))	BDBM141508 (US8921370, 171 | US9656975, 171) Show SMILES Cc1csc(n1)C(=O)NC12CCC(C1)(CCC2)C(=O)Nc1cccc(C)n1 Show InChI InChI=1S/C20H24N4O2S/c1-13-5-3-6-15(21-13)23-18(26)19-7-4-8-20(12-19,10-9-19)24-16(25)17-22-14(2)11-27-17/h3,5-6,11H,4,7-10,12H2,1-2H3,(H,24,25)(H,21,23,26)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	65	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
H. Lundbeck A/S US Patent					Assay Description Binding assays were performed as described in [J. A. O'Brien et al. Mol Pharmacol., 2003, 64, 731-740] with slight modifications, including that ...				US Patent US9656975 (2017) BindingDB Entry DOI: 10.7270/Q29G5PVM
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Homo sapiens (Human))	BDBM141508 (US8921370, 171 | US9656975, 171) Show SMILES Cc1csc(n1)C(=O)NC12CCC(C1)(CCC2)C(=O)Nc1cccc(C)n1 Show InChI InChI=1S/C20H24N4O2S/c1-13-5-3-6-15(21-13)23-18(26)19-7-4-8-20(12-19,10-9-19)24-16(25)17-22-14(2)11-27-17/h3,5-6,11H,4,7-10,12H2,1-2H3,(H,24,25)(H,21,23,26)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	65	-9.80	n/a	n/a	n/a	n/a	n/a	7.4	25
H. Lundbeck A/S US Patent					Assay Description Binding assays were performed as described in [J. A. O'Brien et al. Mol. Pharmacol., 2003, 64, 731-740] with slight modifications, including that a r...				US Patent US8921370 (2014) BindingDB Entry DOI: 10.7270/Q2CR5S3C
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, kainate 1 (Homo sapiens (Human))	BDBM141508 (US8921370, 171 | US9656975, 171) Show SMILES Cc1csc(n1)C(=O)NC12CCC(C1)(CCC2)C(=O)Nc1cccc(C)n1 Show InChI InChI=1S/C20H24N4O2S/c1-13-5-3-6-15(21-13)23-18(26)19-7-4-8-20(12-19,10-9-19)24-16(25)17-22-14(2)11-27-17/h3,5-6,11H,4,7-10,12H2,1-2H3,(H,24,25)(H,21,23,26)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4.70	n/a	n/a	n/a	n/a	n/a	n/a
H. Lundbeck A/S US Patent					Assay Description Binding assays were performed as described in [J. A. O'Brien et al. Mol Pharmacol., 2003, 64, 731-740] with slight modifications, including that ...				US Patent US9656975 (2017) BindingDB Entry DOI: 10.7270/Q29G5PVM
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Homo sapiens (Human))	BDBM141508 (US8921370, 171 | US9656975, 171) Show SMILES Cc1csc(n1)C(=O)NC12CCC(C1)(CCC2)C(=O)Nc1cccc(C)n1 Show InChI InChI=1S/C20H24N4O2S/c1-13-5-3-6-15(21-13)23-18(26)19-7-4-8-20(12-19,10-9-19)24-16(25)17-22-14(2)11-27-17/h3,5-6,11H,4,7-10,12H2,1-2H3,(H,24,25)(H,21,23,26)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4.70	n/a	n/a	n/a	n/a	7.4	37
H. Lundbeck A/S US Patent					Assay Description The cDNA for rat metabotropic glutamate receptor 5 (rmGluR5) and the cDNA for human metabotropic glutamate receptor 5 (rmGluR5) were generous gifts f...				US Patent US8921370 (2014) BindingDB Entry DOI: 10.7270/Q2CR5S3C
					More data for this Ligand-Target Pair