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SMILES: O=C1NCc2c1c-1c(Cc3ccccc-13)c1sc3ccccc3c21

InChI Key: InChIKey=IJICOKICFQCHBP-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 14183   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Mitogen-activated protein kinase kinase kinase 11 (Homo sapiens (Human))	BDBM14183 (3-thia-13-azahexacyclo[14.7.0.0^{2,10}.0^{4,9}.0^{...) Show SMILES O=C1NCc2c1c-1c(Cc3ccccc-13)c1sc3ccccc3c21 Show InChI InChI=1S/C21H13NOS/c23-21-19-15(10-22-21)18-13-7-3-4-8-16(13)24-20(18)14-9-11-5-1-2-6-12(11)17(14)19/h1-8H,9-10H2,(H,22,23)	PDB NCI pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	157	n/a	n/a	n/a	n/a	n/a	n/a
Cephalon					Assay Description The MLK1, MLK2, and MLK3 assays were performed using the Millipore multiscreen trichloroacetic acid (TCA) in-plate format. IC50 values were calculate...				J Med Chem 50: 433-41 (2007) Article DOI: 10.1021/jm051074u BindingDB Entry DOI: 10.7270/Q2HT2MJX
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 9 (Homo sapiens (Human))	BDBM14183 (3-thia-13-azahexacyclo[14.7.0.0^{2,10}.0^{4,9}.0^{...) Show SMILES O=C1NCc2c1c-1c(Cc3ccccc-13)c1sc3ccccc3c21 Show InChI InChI=1S/C21H13NOS/c23-21-19-15(10-22-21)18-13-7-3-4-8-16(13)24-20(18)14-9-11-5-1-2-6-12(11)17(14)19/h1-8H,9-10H2,(H,22,23)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	482	n/a	n/a	n/a	n/a	7.2	37
Cephalon					Assay Description The MLK1, MLK2, and MLK3 assays were performed using the Millipore multiscreen trichloroacetic acid (TCA) in-plate format. IC50 values were calculate...				J Med Chem 50: 433-41 (2007) Article DOI: 10.1021/jm051074u BindingDB Entry DOI: 10.7270/Q2HT2MJX
					More data for this Ligand-Target Pair