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BDBM142619 US8933228, 10

SMILES: COc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc3[nH]c(=O)n(C)c23)c2ccccc12)C(C)(C)C

InChI Key: InChIKey=GRFBNEAPKLWFPA-UHFFFAOYSA-N

Data: 4 IC50

Find this compound or compounds like it in BindingDB or PDB:
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 142619   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
MAP kinase p38


(Homo sapiens (human))
BDBM142619
PNG
(US8933228, 10)
Show SMILES COc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc3[nH]c(=O)n(C)c23)c2ccccc12)C(C)(C)C
Show InChI InChI=1S/C32H31N7O4/c1-32(2,3)26-18-27(39(37-26)19-10-12-20(42-5)13-11-19)35-30(40)34-23-14-15-24(22-9-7-6-8-21(22)23)43-25-16-17-33-29-28(25)38(4)31(41)36-29/h6-18H,1-5H3,(H,33,36,41)(H2,34,35,40)
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US Patent
n/an/a 6n/an/an/an/an/an/a



Respivert, Ltd.

US Patent


Assay Description
The enzyme inhibitory activity of test compounds was determined by fluorescence resonance energy transfer (FRET) using synthetic peptides labelled wi...


Citation and Details
More data for this
Ligand-Target Pair
VEGF-receptor 2 and tyrosine-protein kinase SRC


(Homo sapiens (Human))
BDBM142619
PNG
(US8933228, 10)
Show SMILES COc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc3[nH]c(=O)n(C)c23)c2ccccc12)C(C)(C)C
Show InChI InChI=1S/C32H31N7O4/c1-32(2,3)26-18-27(39(37-26)19-10-12-20(42-5)13-11-19)35-30(40)34-23-14-15-24(22-9-7-6-8-21(22)23)43-25-16-17-33-29-28(25)38(4)31(41)36-29/h6-18H,1-5H3,(H,33,36,41)(H2,34,35,40)
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US Patent
n/an/a 7n/an/an/an/an/an/a



Respivert, Ltd.

US Patent


Assay Description
The enzyme inhibitory activity of test compounds was determined by fluorescence resonance energy transfer (FRET) using synthetic peptides labelled wi...


Citation and Details
More data for this
Ligand-Target Pair
SRC


(Homo sapiens)
BDBM142619
PNG
(US8933228, 10)
Show SMILES COc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc3[nH]c(=O)n(C)c23)c2ccccc12)C(C)(C)C
Show InChI InChI=1S/C32H31N7O4/c1-32(2,3)26-18-27(39(37-26)19-10-12-20(42-5)13-11-19)35-30(40)34-23-14-15-24(22-9-7-6-8-21(22)23)43-25-16-17-33-29-28(25)38(4)31(41)36-29/h6-18H,1-5H3,(H,33,36,41)(H2,34,35,40)
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US Patent
n/an/a 3n/an/an/an/an/an/a



Respivert, Ltd.

US Patent


Assay Description
The enzyme inhibitory activity of test compounds was determined by fluorescence resonance energy transfer (FRET) using synthetic peptides labelled wi...


Citation and Details
More data for this
Ligand-Target Pair
p38 delta/gamma


(Homo sapiens (Human))
BDBM142619
PNG
(US8933228, 10)
Show SMILES COc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc3[nH]c(=O)n(C)c23)c2ccccc12)C(C)(C)C
Show InChI InChI=1S/C32H31N7O4/c1-32(2,3)26-18-27(39(37-26)19-10-12-20(42-5)13-11-19)35-30(40)34-23-14-15-24(22-9-7-6-8-21(22)23)43-25-16-17-33-29-28(25)38(4)31(41)36-29/h6-18H,1-5H3,(H,33,36,41)(H2,34,35,40)
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US Patent
n/an/a 45n/an/an/an/an/an/a



Respivert, Ltd.

US Patent


Assay Description
The enzyme inhibitory activity of test compounds was determined by fluorescence resonance energy transfer (FRET) using synthetic peptides labelled wi...


Citation and Details
More data for this
Ligand-Target Pair