BDBM143317 US8940893, 2

SMILES: CN(C)C\C=C\C(=O)N1CC2(CC(C2)n2nc(-c3ccc(Oc4ccccc4)cc3)c3c(N)ncnc23)C1

InChI Key: InChIKey=YSWLOVMGVYDHPU-RMKNXTFCSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 143317   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase BTK (Homo sapiens (Human))	BDBM143317 (US8940893, 2) Show SMILES CN(C)C\C=C\C(=O)N1CC2(CC(C2)n2nc(-c3ccc(Oc4ccccc4)cc3)c3c(N)ncnc23)C1 Show InChI InChI=1S/C29H31N7O2/c1-34(2)14-6-9-24(37)35-17-29(18-35)15-21(16-29)36-28-25(27(30)31-19-32-28)26(33-36)20-10-12-23(13-11-20)38-22-7-4-3-5-8-22/h3-13,19,21H,14-18H2,1-2H3,(H2,30,31,32)/b9-6+	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.80	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim International GmbH US Patent					Assay Description An HTRF assay (Cisbio KinEASE-TK cat #62TKOPEC) was performed to quantitate the ability of test compounds to inhibit BTK mediated phosphorylation of ...				US Patent US8940893 (2015) BindingDB Entry DOI: 10.7270/Q2PV6J3P
					More data for this Ligand-Target Pair