null

SMILES: CCN1CCN(CCn2nc3C(=O)N(C(c3c2C(C)C)c2ccc(Cl)cc2)c2cccc(Cl)c2F)C1=O

InChI Key: InChIKey=KAKMQHCSBWFALW-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 143345   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Protein Mdm4 (Homo sapiens (Human))	BDBM143345 (US8969341, 13) Show SMILES CCN1CCN(CCn2nc3C(=O)N(C(c3c2C(C)C)c2ccc(Cl)cc2)c2cccc(Cl)c2F)C1=O Show InChI InChI=1S/C27H28Cl2FN5O2/c1-4-32-12-13-33(27(32)37)14-15-34-24(16(2)3)21-23(31-34)26(36)35(20-7-5-6-19(29)22(20)30)25(21)17-8-10-18(28)11-9-17/h5-11,16,25H,4,12-15H2,1-3H3	PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	3.24E+4	n/a	n/a	n/a	n/a	n/a	n/a
Novartis AG US Patent					Assay Description The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...				US Patent US8969341 (2015) BindingDB Entry DOI: 10.7270/Q2K35SC8
					More data for this Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human))	BDBM143345 (US8969341, 13) Show SMILES CCN1CCN(CCn2nc3C(=O)N(C(c3c2C(C)C)c2ccc(Cl)cc2)c2cccc(Cl)c2F)C1=O Show InChI InChI=1S/C27H28Cl2FN5O2/c1-4-32-12-13-33(27(32)37)14-15-34-24(16(2)3)21-23(31-34)26(36)35(20-7-5-6-19(29)22(20)30)25(21)17-8-10-18(28)11-9-17/h5-11,16,25H,4,12-15H2,1-3H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	8.90	n/a	n/a	n/a	n/a	n/a	n/a
Novartis AG US Patent					Assay Description The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...				US Patent US8969341 (2015) BindingDB Entry DOI: 10.7270/Q2K35SC8
					More data for this Ligand-Target Pair