null

SMILES: CC(C)c1c2C(N(C(=O)c2nn1-c1ccc(cc1C)C#N)c1cccc(Cl)c1F)c1ccc(Cl)cc1C

InChI Key: InChIKey=VCGVUTSFODIAFH-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 143431   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Protein Mdm4 (Homo sapiens (Human))	BDBM143431 (US8969341, 80) Show SMILES CC(C)c1c2C(N(C(=O)c2nn1-c1ccc(cc1C)C#N)c1cccc(Cl)c1F)c1ccc(Cl)cc1C Show InChI InChI=1S/C29H23Cl2FN4O/c1-15(2)27-24-26(34-36(27)22-11-8-18(14-33)12-17(22)4)29(37)35(23-7-5-6-21(31)25(23)32)28(24)20-10-9-19(30)13-16(20)3/h5-13,15,28H,1-4H3	PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	2.12E+3	n/a	n/a	n/a	n/a	n/a	n/a
Novartis AG US Patent					Assay Description The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...				US Patent US8969341 (2015) BindingDB Entry DOI: 10.7270/Q2K35SC8
					More data for this Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human))	BDBM143431 (US8969341, 80) Show SMILES CC(C)c1c2C(N(C(=O)c2nn1-c1ccc(cc1C)C#N)c1cccc(Cl)c1F)c1ccc(Cl)cc1C Show InChI InChI=1S/C29H23Cl2FN4O/c1-15(2)27-24-26(34-36(27)22-11-8-18(14-33)12-17(22)4)29(37)35(23-7-5-6-21(31)25(23)32)28(24)20-10-9-19(30)13-16(20)3/h5-13,15,28H,1-4H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	3.20	n/a	n/a	n/a	n/a	n/a	n/a
Novartis AG US Patent					Assay Description The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...				US Patent US8969341 (2015) BindingDB Entry DOI: 10.7270/Q2K35SC8
					More data for this Ligand-Target Pair