BDBM143533 US8969341, 136

SMILES: COc1ccc(cc1-n1nc2C(=O)N(C(c2c1C(C)C)c1ccc(cc1)[N+]#[C-])c1cc(Cl)ccc1C)C#N

InChI Key: InChIKey=KEUYAOJPQJIQBZ-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 143533   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
MDM2-MDMX (Homo sapiens (Human))	BDBM143533 (US8969341, 136) Show SMILES COc1ccc(cc1-n1nc2C(=O)N(C(c2c1C(C)C)c1ccc(cc1)[N+]#[C-])c1cc(Cl)ccc1C)C#N Show InChI InChI=1S/C30H24ClN5O2/c1-17(2)28-26-27(34-36(28)24-14-19(16-32)7-13-25(24)38-5)30(37)35(23-15-21(31)10-6-18(23)3)29(26)20-8-11-22(33-4)12-9-20/h6-15,17,29H,1-3,5H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.242	n/a	n/a	n/a	n/a	n/a	n/a
Novartis AG US Patent					Assay Description The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...				US Patent US8969341 (2015) BindingDB Entry DOI: 10.7270/Q2K35SC8
					More data for this Ligand-Target Pair