BDBM143541 US8969341, 138

SMILES: COc1ccc(cc1-n1nc2C(=O)N(C(c2c1C(C)C)c1ccc(cc1C)[N+]#[C-])c1cc(Cl)ccc1C)C#N

InChI Key: InChIKey=XZSCIWBDQSNTCS-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 143541   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
MDM2-MDMX (Homo sapiens (Human))	BDBM143541 (US8969341, 138) Show SMILES COc1ccc(cc1-n1nc2C(=O)N(C(c2c1C(C)C)c1ccc(cc1C)[N+]#[C-])c1cc(Cl)ccc1C)C#N Show InChI InChI=1S/C31H26ClN5O2/c1-17(2)29-27-28(35-37(29)25-14-20(16-33)8-12-26(25)39-6)31(38)36(24-15-21(32)9-7-18(24)3)30(27)23-11-10-22(34-5)13-19(23)4/h7-15,17,30H,1-4,6H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.176	n/a	n/a	n/a	n/a	n/a	n/a
Novartis AG US Patent					Assay Description The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...				US Patent US8969341 (2015) BindingDB Entry DOI: 10.7270/Q2K35SC8
					More data for this Ligand-Target Pair