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SMILES: CNc1ncc(c(OC)n1)-n1nc2C(=O)N(C(c2c1C(C)C)c1ccc(cc1)C#N)c1cc(Cl)c(=O)n(C)c1

InChI Key: InChIKey=LWGPOQSLGYFKSK-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 143661   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM143661
PNG
(US8969341, 174)
Show SMILES CNc1ncc(c(OC)n1)-n1nc2C(=O)N(C(c2c1C(C)C)c1ccc(cc1)C#N)c1cc(Cl)c(=O)n(C)c1
Show InChI InChI=1S/C27H25ClN8O3/c1-14(2)22-20-21(33-36(22)19-12-31-27(30-3)32-24(19)39-5)26(38)35(17-10-18(28)25(37)34(4)13-17)23(20)16-8-6-15(11-29)7-9-16/h6-10,12-14,23H,1-5H3,(H,30,31,32)
PDB
MMDB

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KEGG

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Similars
US Patent
n/an/a 0.663n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8969341 (2015)


BindingDB Entry DOI: 10.7270/Q2K35SC8
More data for this
Ligand-Target Pair