BDBM143703 US8969341, 191

SMILES: COc1nc(ncc1-n1nc2C(=O)N(C(c2c1C(C)C)c1ccc(C#N)c(F)c1)c1cc(Cl)cn(C)c1=O)N(C)C

InChI Key: InChIKey=QCBBDTOZLNYFGQ-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 143703   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
MDM2-MDMX (Homo sapiens (Human))	BDBM143703 (US8969341, 191) Show SMILES COc1nc(ncc1-n1nc2C(=O)N(C(c2c1C(C)C)c1ccc(C#N)c(F)c1)c1cc(Cl)cn(C)c1=O)N(C)C Show InChI InChI=1S/C28H26ClFN8O3/c1-14(2)23-21-22(34-38(23)20-12-32-28(35(3)4)33-25(20)41-6)27(40)37(19-10-17(29)13-36(5)26(19)39)24(21)15-7-8-16(11-31)18(30)9-15/h7-10,12-14,24H,1-6H3	PDB MMDB NCI pathway Reactome pathway KEGG B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.376	n/a	n/a	n/a	n/a	n/a	n/a
Novartis AG US Patent					Assay Description The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...				US Patent US8969341 (2015) BindingDB Entry DOI: 10.7270/Q2K35SC8
					More data for this Ligand-Target Pair