BDBM143719 US8969341, 195

SMILES: COc1nc(ncc1-n1nc2C(=O)N(C(c2c1C(C)C)c1ccc(Cl)c(F)c1)c1cc(Cl)cn(C)c1=O)N(C)C

InChI Key: InChIKey=RNZZSMCPSZIPLM-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 143719   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
MDM2-MDMX (Homo sapiens (Human))	BDBM143719 (US8969341, 195) Show SMILES COc1nc(ncc1-n1nc2C(=O)N(C(c2c1C(C)C)c1ccc(Cl)c(F)c1)c1cc(Cl)cn(C)c1=O)N(C)C Show InChI InChI=1S/C27H26Cl2FN7O3/c1-13(2)22-20-21(33-37(22)19-11-31-27(34(3)4)32-24(19)40-6)26(39)36(18-10-15(28)12-35(5)25(18)38)23(20)14-7-8-16(29)17(30)9-14/h7-13,23H,1-6H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.128	n/a	n/a	n/a	n/a	n/a	n/a
Novartis AG US Patent					Assay Description The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...				US Patent US8969341 (2015) BindingDB Entry DOI: 10.7270/Q2K35SC8
					More data for this Ligand-Target Pair