BDBM14406 5-(5-Acetyl-2-isobutoxy-3-pyridinyl)-3-ethyl-2-(1-methyl-3-azetidinyl)-2,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one::5-[5-acetyl-2-(2-methylpropoxy)pyridin-3-yl]-3-ethyl-2-(1-methylazetidin-3-yl)-2H,6H,7H-pyrazolo[4,3-d]pyrimidin-7-one::Sildenafil 5-methyl ketone analogue 30

SMILES: CCc1n(nc2c1nc([nH]c2=O)-c1cc(cnc1OCC(C)C)C(C)=O)C1CN(C)C1

InChI Key: InChIKey=RGQBMDVLKYPCTO-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 14406   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
cGMP-specific 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM14406 (5-(5-Acetyl-2-isobutoxy-3-pyridinyl)-3-ethyl-2-(1-...) Show SMILES CCc1n(nc2c1nc([nH]c2=O)-c1cc(cnc1OCC(C)C)C(C)=O)C1CN(C)C1 Show InChI InChI=1S/C22H28N6O3/c1-6-17-18-19(26-28(17)15-9-27(5)10-15)21(30)25-20(24-18)16-7-14(13(4)29)8-23-22(16)31-11-12(2)3/h7-8,12,15H,6,9-11H2,1-5H3,(H,24,25,30)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	8.20	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer					Assay Description PDE5 or PDE6 catalytic activity was monitored by measuring the hydrolysis of [3H]-cGMP to [3H]-GMP using a scintillation proximity assay (SPA). [3H]-...				J Med Chem 49: 3581-94 (2006) Article DOI: 10.1021/jm060113e BindingDB Entry DOI: 10.7270/Q2C24TP4
					More data for this Ligand-Target Pair