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SMILES: Cn1nc(Nc2nccc(n2)-c2ccc(OC3CCOCC3)c(c2)C#N)ccc1=O

InChI Key: InChIKey=ZUDLFDOJAKMMDT-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 144131   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Inhibitor of nuclear factor kappa-B kinase subunit epsilon (Homo sapiens (Human))	BDBM144131 (US8969335, A68) Show SMILES Cn1nc(Nc2nccc(n2)-c2ccc(OC3CCOCC3)c(c2)C#N)ccc1=O Show InChI InChI=1S/C21H20N6O3/c1-27-20(28)5-4-19(26-27)25-21-23-9-6-17(24-21)14-2-3-18(15(12-14)13-22)30-16-7-10-29-11-8-16/h2-6,9,12,16H,7-8,10-11H2,1H3,(H,23,24,25,26)	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	200	n/a	n/a	n/a	n/a	7.5	30
MERCK PATENT GmbH US Patent					Assay Description 1 nM IKKe, 800 nM biotinylated IkBalpha(19-42) peptide (Biotin-C6-C6-GLKKERLLDDRHDSGLDSMKDEE) and 10 μM ATP (spiked with 0.3 uCi of 33P-ATP/well) ar...				US Patent US8969335 (2015) BindingDB Entry DOI: 10.7270/Q25X27NN
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase TBK1 (Homo sapiens (Human))	BDBM144131 (US8969335, A68) Show SMILES Cn1nc(Nc2nccc(n2)-c2ccc(OC3CCOCC3)c(c2)C#N)ccc1=O Show InChI InChI=1S/C21H20N6O3/c1-27-20(28)5-4-19(26-27)25-21-23-9-6-17(24-21)14-2-3-18(15(12-14)13-22)30-16-7-10-29-11-8-16/h2-6,9,12,16H,7-8,10-11H2,1H3,(H,23,24,25,26)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	160	n/a	n/a	n/a	n/a	7.5	30
MERCK PATENT GmbH US Patent					Assay Description The kinase assay is performed as 384-well flashplate assay (for example for Topcount measurement).0.6 nM TANK binding kinase (TBK1), 800 nM biotinyla...				US Patent US8969335 (2015) BindingDB Entry DOI: 10.7270/Q25X27NN
					More data for this Ligand-Target Pair