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SMILES: N#Cc1cc(ccc1OC1CCOCC1)-c1ccnc(Nc2nccc(n2)C2CCNCC2)c1

InChI Key: InChIKey=CGELHDCKISPXTF-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 144152   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Inhibitor of nuclear factor kappa-B kinase subunit epsilon (Homo sapiens (Human))	BDBM144152 (US8969335, A89) Show SMILES N#Cc1cc(ccc1OC1CCOCC1)-c1ccnc(Nc2nccc(n2)C2CCNCC2)c1 Show InChI InChI=1S/C26H28N6O2/c27-17-21-15-19(1-2-24(21)34-22-7-13-33-14-8-22)20-5-11-29-25(16-20)32-26-30-12-6-23(31-26)18-3-9-28-10-4-18/h1-2,5-6,11-12,15-16,18,22,28H,3-4,7-10,13-14H2,(H,29,30,31,32)	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	120	n/a	n/a	n/a	n/a	7.5	30
MERCK PATENT GmbH US Patent					Assay Description 1 nM IKKe, 800 nM biotinylated IkBalpha(19-42) peptide (Biotin-C6-C6-GLKKERLLDDRHDSGLDSMKDEE) and 10 μM ATP (spiked with 0.3 uCi of 33P-ATP/well) ar...				US Patent US8969335 (2015) BindingDB Entry DOI: 10.7270/Q25X27NN
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase TBK1 (Homo sapiens (Human))	BDBM144152 (US8969335, A89) Show SMILES N#Cc1cc(ccc1OC1CCOCC1)-c1ccnc(Nc2nccc(n2)C2CCNCC2)c1 Show InChI InChI=1S/C26H28N6O2/c27-17-21-15-19(1-2-24(21)34-22-7-13-33-14-8-22)20-5-11-29-25(16-20)32-26-30-12-6-23(31-26)18-3-9-28-10-4-18/h1-2,5-6,11-12,15-16,18,22,28H,3-4,7-10,13-14H2,(H,29,30,31,32)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	140	n/a	n/a	n/a	n/a	7.5	30
MERCK PATENT GmbH US Patent					Assay Description The kinase assay is performed as 384-well flashplate assay (for example for Topcount measurement).0.6 nM TANK binding kinase (TBK1), 800 nM biotinyla...				US Patent US8969335 (2015) BindingDB Entry DOI: 10.7270/Q25X27NN
					More data for this Ligand-Target Pair