BDBM144184 US8969335, A5

SMILES: Cn1ccc(Nc2cc(ccn2)-c2ccc(OC3CCOCC3)c(c2)C#N)n1

InChI Key: InChIKey=UYIHWPCEDZKSLA-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 144184   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Inhibitor of nuclear factor kappa-B kinase subunit epsilon (Homo sapiens (Human))	BDBM144184 (US8969335, A5) Show SMILES Cn1ccc(Nc2cc(ccn2)-c2ccc(OC3CCOCC3)c(c2)C#N)n1 Show InChI InChI=1S/C21H21N5O2/c1-26-9-5-20(25-26)24-21-13-16(4-8-23-21)15-2-3-19(17(12-15)14-22)28-18-6-10-27-11-7-18/h2-5,8-9,12-13,18H,6-7,10-11H2,1H3,(H,23,24,25)	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	110	n/a	n/a	n/a	n/a	7.5	30
MERCK PATENT GmbH US Patent					Assay Description 1 nM IKKe, 800 nM biotinylated IkBalpha(19-42) peptide (Biotin-C6-C6-GLKKERLLDDRHDSGLDSMKDEE) and 10 μM ATP (spiked with 0.3 uCi of 33P-ATP/well) ar...				US Patent US8969335 (2015) BindingDB Entry DOI: 10.7270/Q25X27NN
					More data for this Ligand-Target Pair
Protein cereblon/Serine/threonine-protein kinase TBK1 (Homo sapiens (Human))	BDBM144184 (US8969335, A5) Show SMILES Cn1ccc(Nc2cc(ccn2)-c2ccc(OC3CCOCC3)c(c2)C#N)n1 Show InChI InChI=1S/C21H21N5O2/c1-26-9-5-20(25-26)24-21-13-16(4-8-23-21)15-2-3-19(17(12-15)14-22)28-18-6-10-27-11-7-18/h2-5,8-9,12-13,18H,6-7,10-11H2,1H3,(H,23,24,25)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	97	n/a	n/a	n/a	n/a	7.5	30
MERCK PATENT GmbH US Patent					Assay Description The kinase assay is performed as 384-well flashplate assay (for example for Topcount measurement).0.6 nM TANK binding kinase (TBK1), 800 nM biotinyla...				US Patent US8969335 (2015) BindingDB Entry DOI: 10.7270/Q25X27NN
					More data for this Ligand-Target Pair