null

SMILES: OCC(=O)N1CCC(CCn2cc(Nc3cc(ccn3)-c3ccc(OC4CCOCC4)c(c3)C#N)cn2)CC1

InChI Key: InChIKey=PNYUSFRZJAPJCP-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 144205   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Inhibitor of nuclear factor kappa-B kinase subunit epsilon (Homo sapiens (Human))	BDBM144205 (US8969335, A29) Show SMILES OCC(=O)N1CCC(CCn2cc(Nc3cc(ccn3)-c3ccc(OC4CCOCC4)c(c3)C#N)cn2)CC1 Show InChI InChI=1S/C29H34N6O4/c30-17-24-15-22(1-2-27(24)39-26-7-13-38-14-8-26)23-3-9-31-28(16-23)33-25-18-32-35(19-25)12-6-21-4-10-34(11-5-21)29(37)20-36/h1-3,9,15-16,18-19,21,26,36H,4-8,10-14,20H2,(H,31,33)	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	88	n/a	n/a	n/a	n/a	7.5	30
MERCK PATENT GmbH US Patent					Assay Description 1 nM IKKe, 800 nM biotinylated IkBalpha(19-42) peptide (Biotin-C6-C6-GLKKERLLDDRHDSGLDSMKDEE) and 10 μM ATP (spiked with 0.3 uCi of 33P-ATP/well) ar...				US Patent US8969335 (2015) BindingDB Entry DOI: 10.7270/Q25X27NN
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase TBK1 (Homo sapiens (Human))	BDBM144205 (US8969335, A29) Show SMILES OCC(=O)N1CCC(CCn2cc(Nc3cc(ccn3)-c3ccc(OC4CCOCC4)c(c3)C#N)cn2)CC1 Show InChI InChI=1S/C29H34N6O4/c30-17-24-15-22(1-2-27(24)39-26-7-13-38-14-8-26)23-3-9-31-28(16-23)33-25-18-32-35(19-25)12-6-21-4-10-34(11-5-21)29(37)20-36/h1-3,9,15-16,18-19,21,26,36H,4-8,10-14,20H2,(H,31,33)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	120	n/a	n/a	n/a	n/a	7.5	30
MERCK PATENT GmbH US Patent					Assay Description The kinase assay is performed as 384-well flashplate assay (for example for Topcount measurement).0.6 nM TANK binding kinase (TBK1), 800 nM biotinyla...				US Patent US8969335 (2015) BindingDB Entry DOI: 10.7270/Q25X27NN
					More data for this Ligand-Target Pair