null

SMILES: CC(C)(C)c1cc(Nc2cc(ccn2)-c2ccc(OC3CCOCC3)c(c2)C#N)on1

InChI Key: InChIKey=IVAFRTWUCSWUMI-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 144207   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Inhibitor of nuclear factor kappa-B kinase subunit epsilon (Homo sapiens (Human))	BDBM144207 (US8969335, A31) Show SMILES CC(C)(C)c1cc(Nc2cc(ccn2)-c2ccc(OC3CCOCC3)c(c2)C#N)on1 Show InChI InChI=1S/C24H26N4O3/c1-24(2,3)21-14-23(31-28-21)27-22-13-17(6-9-26-22)16-4-5-20(18(12-16)15-25)30-19-7-10-29-11-8-19/h4-6,9,12-14,19H,7-8,10-11H2,1-3H3,(H,26,27)	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	850	n/a	n/a	n/a	n/a	7.5	30
MERCK PATENT GmbH US Patent					Assay Description 1 nM IKKe, 800 nM biotinylated IkBalpha(19-42) peptide (Biotin-C6-C6-GLKKERLLDDRHDSGLDSMKDEE) and 10 μM ATP (spiked with 0.3 uCi of 33P-ATP/well) ar...				US Patent US8969335 (2015) BindingDB Entry DOI: 10.7270/Q25X27NN
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase TBK1 (Homo sapiens (Human))	BDBM144207 (US8969335, A31) Show SMILES CC(C)(C)c1cc(Nc2cc(ccn2)-c2ccc(OC3CCOCC3)c(c2)C#N)on1 Show InChI InChI=1S/C24H26N4O3/c1-24(2,3)21-14-23(31-28-21)27-22-13-17(6-9-26-22)16-4-5-20(18(12-16)15-25)30-19-7-10-29-11-8-19/h4-6,9,12-14,19H,7-8,10-11H2,1-3H3,(H,26,27)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	860	n/a	n/a	n/a	n/a	7.5	30
MERCK PATENT GmbH US Patent					Assay Description The kinase assay is performed as 384-well flashplate assay (for example for Topcount measurement).0.6 nM TANK binding kinase (TBK1), 800 nM biotinyla...				US Patent US8969335 (2015) BindingDB Entry DOI: 10.7270/Q25X27NN
					More data for this Ligand-Target Pair