BDBM144317 US8969336, 550::US8969336, 579
SMILES: CCc1nc(C(N)=O)c(Nc2ccc(N3CCN(C)CC3)c(F)c2)nc1NC1CCOCC1
InChI Key: InChIKey=WPRKLFMPRRQLFM-UHFFFAOYSA-N
Data: 4 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
EML4 ALK Fusion Protein (Homo sapiens (Human)) | BDBM144317 (US8969336, 550 | US8969336, 579) | PDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
Astellas Pharma Inc.; Kotobuki Pharmaceutical Co., Ltd. US Patent | Assay Description A recombinant retrovirus was created from expression plasmid FLAG-EML4-ALKv1/pMX-iresCD8 in which cDNA for EMLA-ALK fusion protein v1 was integrated,... | US Patent US8969336 (2015) BindingDB Entry DOI: 10.7270/Q2NV9GZW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human)) | BDBM144317 (US8969336, 550 | US8969336, 579) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 0.360 | n/a | n/a | n/a | n/a | n/a | n/a |
Astellas Pharma Inc.; Kotobuki Pharmaceutical Co., Ltd. US Patent | Assay Description A partial protein of only a kinase domain of FLT3 protein was purchased from Carna Biosciences Inc., Japan, and tests were conducted as in Test Examp... | US Patent US8969336 (2015) BindingDB Entry DOI: 10.7270/Q2NV9GZW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Proto-oncogene tyrosine-protein kinase ROS (Homo sapiens (Human)) | BDBM144317 (US8969336, 550 | US8969336, 579) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 0.580 | n/a | n/a | n/a | n/a | n/a | n/a |
Astellas Pharma Inc.; Kotobuki Pharmaceutical Co., Ltd. US Patent | Assay Description A partial protein of only a kinase domain of ROS protein was purchased from Carna Biosciences Inc., Japan, and tests were conducted as in Test Exampl... | US Patent US8969336 (2015) BindingDB Entry DOI: 10.7270/Q2NV9GZW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Proto-oncogene tyrosine-protein kinase receptor Ret (Homo sapiens (Human)) | BDBM144317 (US8969336, 550 | US8969336, 579) | PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 1.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Astellas Pharma Inc.; Kotobuki Pharmaceutical Co., Ltd. US Patent | Assay Description A partial protein of only a kinase domain of RET protein was purchased from Carna Biosciences Inc., Japan. The phosphorylation activity toward a pept... | US Patent US8969336 (2015) BindingDB Entry DOI: 10.7270/Q2NV9GZW | |||||||||||
More data for this Ligand-Target Pair |