BDBM14439 2-quinolone analog 3a::4-[(1-{[4-(3-chlorophenyl)-1-methyl-2-oxo-1,2-dihydroquinolin-6-yl]methyl}-1H-imidazol-5-yl)methyl]benzonitrile

SMILES: Cn1c2ccc(Cn3cncc3Cc3ccc(cc3)C#N)cc2c(cc1=O)-c1cccc(Cl)c1

InChI Key: InChIKey=PHPWMLQIAMSLPU-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 14439   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Geranylgeranyl Transferase (GGTase-I) (Bos taurus (bovine))	BDBM14439 (2-quinolone analog 3a | 4-[(1-{[4-(3-chlorophenyl)...) Show SMILES Cn1c2ccc(Cn3cncc3Cc3ccc(cc3)C#N)cc2c(cc1=O)-c1cccc(Cl)c1 Show InChI InChI=1S/C28H21ClN4O/c1-32-27-10-9-21(12-26(27)25(14-28(32)34)22-3-2-4-23(29)13-22)17-33-18-31-16-24(33)11-19-5-7-20(15-30)8-6-19/h2-10,12-14,16,18H,11,17H2,1H3	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories					Assay Description The in vitro activity of compounds inhibiting GGTase-1 was determined by measuring the transfer of [3H]-geranylgeranylpyrophosphate to substrate Ha-R...				Bioorg Med Chem Lett 15: 2033-9 (2005) Article DOI: 10.1016/j.bmcl.2005.02.062 BindingDB Entry DOI: 10.7270/Q23J3B61
					More data for this Ligand-Target Pair
Protein Farnesyltransferase (PFT) (Bos taurus (bovine))	BDBM14439 (2-quinolone analog 3a | 4-[(1-{[4-(3-chlorophenyl)...) Show SMILES Cn1c2ccc(Cn3cncc3Cc3ccc(cc3)C#N)cc2c(cc1=O)-c1cccc(Cl)c1 Show InChI InChI=1S/C28H21ClN4O/c1-32-27-10-9-21(12-26(27)25(14-28(32)34)22-3-2-4-23(29)13-22)17-33-18-31-16-24(33)11-19-5-7-20(15-30)8-6-19/h2-10,12-14,16,18H,11,17H2,1H3	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7.20	n/a	n/a	n/a	n/a	7.5	37
Abbott Laboratories					Assay Description The in vitro activity of compounds inhibiting FTase was determined by measuring the transfer of [3H]-FPP to substrate Ha-Ras-CVLS. The incorporated r...				Bioorg Med Chem Lett 15: 2033-9 (2005) Article DOI: 10.1016/j.bmcl.2005.02.062 BindingDB Entry DOI: 10.7270/Q23J3B61
					More data for this Ligand-Target Pair