BDBM14443 (1-{[4-(3-chlorophenyl)-1-methyl-2-oxo-1,2-dihydroquinolin-6-yl]methyl}-1H-imidazol-5-yl)(4-cyanophenyl)methyl acetate::2-quinolone analog 3b

SMILES: CC(=O)OC(c1cncn1Cc1ccc2n(C)c(=O)cc(-c3cccc(Cl)c3)c2c1)c1ccc(cc1)C#N

InChI Key: InChIKey=AEABDQQUYLQDMM-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 14443   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Geranylgeranyl Transferase (GGTase-I) (Bos taurus (bovine))	BDBM14443 ((1-{[4-(3-chlorophenyl)-1-methyl-2-oxo-1,2-dihydro...) Show SMILES CC(=O)OC(c1cncn1Cc1ccc2n(C)c(=O)cc(-c3cccc(Cl)c3)c2c1)c1ccc(cc1)C#N Show InChI InChI=1S/C30H23ClN4O3/c1-19(36)38-30(22-9-6-20(15-32)7-10-22)28-16-33-18-35(28)17-21-8-11-27-26(12-21)25(14-29(37)34(27)2)23-4-3-5-24(31)13-23/h3-14,16,18,30H,17H2,1-2H3	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories					Assay Description The in vitro activity of compounds inhibiting GGTase-1 was determined by measuring the transfer of [3H]-geranylgeranylpyrophosphate to substrate Ha-R...				Bioorg Med Chem Lett 15: 2033-9 (2005) Article DOI: 10.1016/j.bmcl.2005.02.062 BindingDB Entry DOI: 10.7270/Q23J3B61
					More data for this Ligand-Target Pair
Protein Farnesyltransferase (PFT) (Bos taurus (bovine))	BDBM14443 ((1-{[4-(3-chlorophenyl)-1-methyl-2-oxo-1,2-dihydro...) Show SMILES CC(=O)OC(c1cncn1Cc1ccc2n(C)c(=O)cc(-c3cccc(Cl)c3)c2c1)c1ccc(cc1)C#N Show InChI InChI=1S/C30H23ClN4O3/c1-19(36)38-30(22-9-6-20(15-32)7-10-22)28-16-33-18-35(28)17-21-8-11-27-26(12-21)25(14-29(37)34(27)2)23-4-3-5-24(31)13-23/h3-14,16,18,30H,17H2,1-2H3	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	7.5	37
Abbott Laboratories					Assay Description The in vitro activity of compounds inhibiting FTase was determined by measuring the transfer of [3H]-FPP to substrate Ha-Ras-CVLS. The incorporated r...				Bioorg Med Chem Lett 15: 2033-9 (2005) Article DOI: 10.1016/j.bmcl.2005.02.062 BindingDB Entry DOI: 10.7270/Q23J3B61
					More data for this Ligand-Target Pair