BDBM14445 2-quinolone analog 21::4-[(1-{[4-(3-chlorophenyl)-1-methyl-2-oxo-1,2-dihydroquinolin-6-yl]methyl}-1H-imidazol-5-yl)methoxy]benzonitrile

SMILES: Cn1c2ccc(Cn3cncc3COc3ccc(cc3)C#N)cc2c(cc1=O)-c1cccc(Cl)c1

InChI Key: InChIKey=MHQZUNDWZPCXIJ-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 14445   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Protein Farnesyltransferase (PFT) (Bos taurus (bovine))	BDBM14445 (2-quinolone analog 21 | 4-[(1-{[4-(3-chlorophenyl)...) Show SMILES Cn1c2ccc(Cn3cncc3COc3ccc(cc3)C#N)cc2c(cc1=O)-c1cccc(Cl)c1 Show InChI InChI=1S/C28H21ClN4O2/c1-32-27-10-7-20(11-26(27)25(13-28(32)34)21-3-2-4-22(29)12-21)16-33-18-31-15-23(33)17-35-24-8-5-19(14-30)6-9-24/h2-13,15,18H,16-17H2,1H3	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	7.5	37
Abbott Laboratories					Assay Description The in vitro activity of compounds inhibiting FTase was determined by measuring the transfer of [3H]-FPP to substrate Ha-Ras-CVLS. The incorporated r...				Bioorg Med Chem Lett 15: 2033-9 (2005) Article DOI: 10.1016/j.bmcl.2005.02.062 BindingDB Entry DOI: 10.7270/Q23J3B61
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