BDBM144450 US8969568, 1

SMILES: C[C@@H](Oc1nc(cc2ncccc12)-c1ccc(OC(F)(F)F)c(F)c1)[C@H]1CNC(=O)C1

InChI Key: InChIKey=MMZWQGKOXSRBCJ-DGCLKSJQSA-N

Data: 1 IC50

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Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 144450   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM144450 (US8969568, 1) Show SMILES C[C@@H](Oc1nc(cc2ncccc12)-c1ccc(OC(F)(F)F)c(F)c1)[C@H]1CNC(=O)C1 |r| Show InChI InChI=1S/C21H17F4N3O3/c1-11(13-8-19(29)27-10-13)30-20-14-3-2-6-26-17(14)9-16(28-20)12-4-5-18(15(22)7-12)31-21(23,24)25/h2-7,9,11,13H,8,10H2,1H3,(H,27,29)/t11-,13-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	13.1	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim Pharma GmbH & Co. KG US Patent					Assay Description Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...				US Patent US8969568 (2015) BindingDB Entry DOI: 10.7270/Q2154FRD
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