BDBM144455 US8969568, 6

SMILES: COc1cc(cc(Cl)c1OC)-c1cc2ncccc2c(OC[C@H]2CNC(=O)C2)n1

InChI Key: InChIKey=IXMPLEQRCXZJSC-GFCCVEGCSA-N

Data: 1 IC50

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Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 144455   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM144455 (US8969568, 6) Show SMILES COc1cc(cc(Cl)c1OC)-c1cc2ncccc2c(OC[C@H]2CNC(=O)C2)n1 |r| Show InChI InChI=1S/C21H20ClN3O4/c1-27-18-8-13(7-15(22)20(18)28-2)16-9-17-14(4-3-5-23-17)21(25-16)29-11-12-6-19(26)24-10-12/h3-5,7-9,12H,6,10-11H2,1-2H3,(H,24,26)/t12-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	25.3	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim Pharma GmbH & Co. KG US Patent					Assay Description Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...				US Patent US8969568 (2015) BindingDB Entry DOI: 10.7270/Q2154FRD
					More data for this Ligand-Target Pair